'Fluorous nanoflow' system is extremely effective for the lanthanide bis(perfluorooctanesulfonyl)amide-catalyzed Mukaiyama aldol reaction with dramatic increase in the reaction rate by the continuously controlled nano feeder. Thus, the acceleration of the aldol reaction was achieved even in the lowest concentration ( < 0.0001 M) of the lanthanide fluorous catalyst and, hence, the reaction completed within seconds as a bi-phase contact time in the micro cell. (C) 2003 Elsevier Ltd. All rights reserved.