2020年5月21日
The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac<inf>1</inf>PIM<inf>1</inf>: Its synthesis and immunomodulatory function
Organic and Biomolecular Chemistry
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- 巻
- 18
- 号
- 19
- 開始ページ
- 3659
- 終了ページ
- 3663
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1039/c9ob02724f
Ac PIM is a potential biosynthetic intermediate for phosphatidylinositol mannosides (PIMs) fromMycobacterium tuberculosis. We achieved the first synthesis of Ac PIM by utilizing an allyl-type protecting group strategy and regioselective phosphorylation of inositol. A very potent agonist of an innate immune receptor DCAR, which is better than previously known agonists, is demonstrated. 1 1 1 1
- リンク情報
- ID情報
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- DOI : 10.1039/c9ob02724f
- ISSN : 1477-0520
- PubMed ID : 32356529
- SCOPUS ID : 85085265218