2019年1月
Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective.
British journal of pharmacology
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- 巻
- 176
- 号
- 2
- 開始ページ
- 155
- 終了ページ
- 176
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/bph.14488
Recent findings suggest that co-expression of NOS2 and COX2 is a strong prognostic indicator in triple-negative breast cancer patients. These two key inflammation-associated enzymes are responsible for the biosynthesis of NO and PGE2 , respectively, and can exert their effect in both an autocrine and paracrine manner. Impairment of their physiological regulation leads to critical changes in both intra-tumoural and intercellular communication with the immune system and their adaptation to the hypoxic tumour micro-environment. Recent studies have also established a key role of NOS2-COX2 in causing metabolic shift. This review provides an extensive overview of the role of NO and PGE2 in shaping communication between the tumour micro-environment composed of tumour and immune cells that in turn favours tumour progression and metastasis. LINKED ARTICLES: This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc.
- リンク情報
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- DOI
- https://doi.org/10.1111/bph.14488
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30152521
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295414
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056153902&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85056153902&origin=inward
- ID情報
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- DOI : 10.1111/bph.14488
- ISSN : 0007-1188
- eISSN : 1476-5381
- PubMed ID : 30152521
- PubMed Central 記事ID : PMC6295414
- SCOPUS ID : 85056153902