This special issue deals with water and food as it applies to water resources and rice production in the Mekong River Basin. The range of papers reflects not only the broad interest but also the complexity of the topic. These reports are mainly based on the research carried out by the project, "Assessment of the Impact of Global-Scale Change in Water Cycles on Food Production and Alternative Policy Scenarios''. Hence the special issue gives a brief overview of the structure, goals, outcomes, and future direction of the above project. What we do in this paper are: (1) giving an overview of the project's structure and goals, (2) stating the five common outcomes and several more specific results, and (3) looking forward to the future direction of the project. The aim of our research is to draw up scenarios for optimum water-resource distribution and to develop social guidelines, measures, and policies to help solving food and environmental problems by developing a world water-food model that emphasizes rice production in Monsoon Asia. We have integrated all of the data gathered and the research results into a food supply and demand model combined with a water-cycle analysis. We included operational factors, such as water-cycle change, water demand, water supply, and water distribution in the model. Emphasis is placed on the use of efficient resource-management technologies for proper use of water resources in agricultural and other sectors. The water-food model has been developed as a tool for evaluating technical decisions derived under various policy scenarios.