2018年6月8日
Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection
CHEMICAL COMMUNICATIONS
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 54
- 号
- 54
- 開始ページ
- 7467
- 終了ページ
- 7470
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c8cc03865a
- 出版者・発行元
- Royal Society of Chemistry
© 2018 The Royal Society of Chemistry. Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.
- リンク情報
- ID情報
-
- DOI : 10.1039/c8cc03865a
- ISSN : 1359-7345