2011年1月
Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat
NEUROSCIENCE LETTERS
- 巻
- 487
- 号
- 1
- 開始ページ
- 103
- 終了ページ
- 106
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.neulet.2010.10.004
- 出版者・発行元
- ELSEVIER IRELAND LTD
The present study investigates the anti-oxidative effects of D-allose on ischemic damage. Rats were subjected to transient middle cerebral artery occlusion (MCAO) for 1 h under pentobarbital anesthesia. D-allose was intravenously infused during occlusion and a further 1 h after reperfusion (400 mg/kg). The effects of D-allose on focal cerebral ischemia were examined by measuring brain damage (infarction and atrophy volume) and behavioral deficits 7 days after MCAO. In another set of rats, apurnic/apyrimidic abasic sites (AP-sites) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were investigated 24h after MCAO to examine the anti-oxidative effects of D-allose. Brain damage and behavioral deficits were significantly decreased by D-allose administration compared to vehicle. The number of AP-sites and 8-OHdG levels were also reduced by D-allose. Thus, the present study suggests that D-allose has anti-oxidative effects and induces neuroprotection in focal cerebral ischemia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.neulet.2010.10.004
- CiNii Articles
- http://ci.nii.ac.jp/naid/10030100325
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20937361
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000285495100023&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1016/j.neulet.2010.10.004
- ISSN : 0304-3940
- CiNii Articles ID : 10030100325
- PubMed ID : 20937361
- Web of Science ID : WOS:000285495100023