Straightforwardly stereo-defined syntheses of (E)- and (Z)-Tamoxifen were described, including a description of chemo-selective activation of (E)-1-bromo-2-iodoalkenes. The (E)-1-bromo-2-iodoalkenes were employed as starting materials; first, the vinylic iodine was transformed into a phenyl group with employing CuTC and PhSnBu3 reagents. Then the resultant vinylic bromine Straightforwardly stereo-defined syntheses of (E)- and (Z)-Tamoxifen were described, including a description of chemo-selective activation of (E)-1-bromo-2-iodoalkenes. The (E)-1-bromo-2-iodoalkenes were employed as starting materials; first, the vinylic iodine was transformed into a phenyl group with employing CuTC and PhSnBu3 reagents. Then the resultant vinylic bromine