2019年12月15日
Interferon-induced transmembrane protein 1 and Myxovirus resistance protein 1 are induced by polyinosinic-polycytidylic acid in cultured hCMEC/D3 human cerebral microvascular endothelial cells.
Journal of neuroimmunology
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- 巻
- 337
- 号
- 開始ページ
- 577047
- 終了ページ
- 577047
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jneuroim.2019.577047
The molecular mechanisms of antiviral innate immune reactions in brain microvascular endothelial cells remain unclear. Interferon (IFN)-induced transmembrane protein 1 (IFITM1) and Myxovirus resistance protein 1 (MX1), the members of IFN-stimulated genes, are known as antiviral molecules. IFITM1 inhibits virus entry into host cell cytoplasm, whereas MX1 antagonizes virus replication. Here we observed that IFITM1 and MX1, and a proinflammatory cytokine IL-6 expression was induced by polyinosinic-polycytidylic acid (poly IC) in hCMEC/D3 human brain microvascular endothelial cells. Poly IC-induced IFITM1 and MX1 expression were decreased by NF-κB inhibitor SN50, IFN regulatory factor 3 inhibitor MRT67307 and human type I IFN neutralizing antibody mixture. These findings suggest that IFITM1 and MX1 may help protect the brain from viruses.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jneuroim.2019.577047
- PubMed ID : 31520792