論文

査読有り
2014年7月

Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma

CANCER SCIENCE
  • Yoshiko Kaku
  • ,
  • Hisao Nagaya
  • ,
  • Ayako Tsuchiya
  • ,
  • Takeshi Kanno
  • ,
  • Akinobu Gotoh
  • ,
  • Akito Tanaka
  • ,
  • Tadashi Shimizu
  • ,
  • Syuhei Nakao
  • ,
  • Chiharu Tabata
  • ,
  • Takashi Nakano
  • ,
  • Tomoyuki Nishizaki

105
7
開始ページ
883
終了ページ
889
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/cas.12429
出版者・発行元
WILEY-BLACKWELL

The newly synthesized naftopidil analogue HUHS1015 reduced cell viability in malignant pleural mesothelioma cell lines MSTO-211H, NCI-H28, NCI-H2052, and NCI-H2452, with the potential greater than that for the anticancer drugs paclitaxel or cisplatin at concentrations higher than 30 mu M. HUHS1015 induced both necrosis and apoptosis of MSTO-211H and NCI-H2052 cells. HUHS1015 upregulated expression of mRNAs for Puma, Hrk, and Noxa in MSTO-211H and NCI-H2052 cells, suggesting HUHS1015-induced mitochondrial apoptosis. HUHS1015 clearly suppressed tumor growth in mice inoculated with NCI-H2052 cells. Taken together, the results of the present study indicate that HUHS1015 could be developed as an effective anticancer drug for treatment of malignant pleural mesothelioma.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1111/cas.12429
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24754309
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000340602800019&DestApp=WOS_CPL

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