2014年7月
Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma
CANCER SCIENCE
- 巻
- 105
- 号
- 7
- 開始ページ
- 883
- 終了ページ
- 889
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/cas.12429
- 出版者・発行元
- WILEY-BLACKWELL
The newly synthesized naftopidil analogue HUHS1015 reduced cell viability in malignant pleural mesothelioma cell lines MSTO-211H, NCI-H28, NCI-H2052, and NCI-H2452, with the potential greater than that for the anticancer drugs paclitaxel or cisplatin at concentrations higher than 30 mu M. HUHS1015 induced both necrosis and apoptosis of MSTO-211H and NCI-H2052 cells. HUHS1015 upregulated expression of mRNAs for Puma, Hrk, and Noxa in MSTO-211H and NCI-H2052 cells, suggesting HUHS1015-induced mitochondrial apoptosis. HUHS1015 clearly suppressed tumor growth in mice inoculated with NCI-H2052 cells. Taken together, the results of the present study indicate that HUHS1015 could be developed as an effective anticancer drug for treatment of malignant pleural mesothelioma.
- リンク情報
- ID情報
-
- DOI : 10.1111/cas.12429
- ISSN : 1347-9032
- eISSN : 1349-7006
- PubMed ID : 24754309
- Web of Science ID : WOS:000340602800019