2011
Porous scaffolds consisting of collagen, chondroitin sulfate, and hydroxyapatite with enhanced biodegradable resistance for cartilage regeneration
Materials Research Society symposia proceedings
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- Volume
- 1301
- Number
- First page
- 117
- Last page
- 123
- Language
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1557/opl.2011.535
- Publisher
- Springer Science and Business Media LLC
<title>ABSTRACT</title>Porous scaffolds of alkaline-soluble collagen including nanocomposite
particles of chondroitin sulfate and low crystalline hydroxyapatite for
cartilage regeneration were fabricated by freeze-drying and thermal
dehydration treatments; porous collagen scaffolds were also synthesized as a
reference. The scaffolds were cross-linked using glutaraldehyde (GA) vapor
treatment in order to enhance biodegradable resistance. Microstructural
observation with scanning electron microscope indicated that the scaffolds
with and without GA cross-linkage had open pores between 130 to 200 μm in
diameter and well-interconnected pores of 10 to 30 μm even after
cross-linkage. <italic>In vitro</italic> biodegradable resistance to
collagenase was significantly enhanced by GA cross-linking of the scaffolds.
All these results suggest that the GA cross-linked scaffolds consisting of
collagen, chondroitin sulfate, and low crystalline hydroxyapatite have
suitable microporous structures and long-term biochemical stability for
cartilage tissue engineering.
particles of chondroitin sulfate and low crystalline hydroxyapatite for
cartilage regeneration were fabricated by freeze-drying and thermal
dehydration treatments; porous collagen scaffolds were also synthesized as a
reference. The scaffolds were cross-linked using glutaraldehyde (GA) vapor
treatment in order to enhance biodegradable resistance. Microstructural
observation with scanning electron microscope indicated that the scaffolds
with and without GA cross-linkage had open pores between 130 to 200 μm in
diameter and well-interconnected pores of 10 to 30 μm even after
cross-linkage. <italic>In vitro</italic> biodegradable resistance to
collagenase was significantly enhanced by GA cross-linking of the scaffolds.
All these results suggest that the GA cross-linked scaffolds consisting of
collagen, chondroitin sulfate, and low crystalline hydroxyapatite have
suitable microporous structures and long-term biochemical stability for
cartilage tissue engineering.
- Link information
- ID information
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- DOI : 10.1557/opl.2011.535
- ISSN : 0272-9172
- eISSN : 1946-4274