2014年
4-1BB chimeric antigen receptors
Cancer Journal (United States)
- ,
- ,
- 巻
- 20
- 号
- 2
- 開始ページ
- 134
- 終了ページ
- 140
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1097/PPO.0000000000000028
- 出版者・発行元
- Lippincott Williams and Wilkins
In addition to T-cell receptor signals, T lymphocytes require costimulatory signals for robust activation. Among these, those mediated by 4-1BB (CD137, TNFRSF9) are critical for tumor immunity. 4-1BB is expressed in T-cell receptor-activated lymphocytes as well as natural killer cells and other hematopoietic and nonhematopoietic cells. 4-1BB ligation induces a signaling cascade that results in cytokine production, expression of antiapoptotic molecules, and enhanced immune responses. In line with the described function of 4-1BB, its addition to CD3ζ chimeric antigen receptors (CARs) increases their capacity to provoke T-cell expansion and antitumor activity. The results of preclinical studies with 4-1BB CARs have been corroborated by encouraging results from clinical trials. Advantages and disadvantages of 4-1BB CARs versus CARs bearing other costimulatory components remain to be fully elucidated. In this review, we discuss the properties of 4-1BB, the design of 4-1BB CARs, and the function of T lymphocytes and natural killer cells expressing them. Copyright © 2014 Lippincott Williams &
Wilkins.
Wilkins.
- リンク情報
- ID情報
-
- DOI : 10.1097/PPO.0000000000000028
- ISSN : 1540-336X
- ISSN : 1528-9117
- PubMed ID : 24667959
- SCOPUS ID : 84897566595