2018年5月1日
Tricin inhibits the CCL5 induction required for efficient growth of human cytomegalovirus
Microbiology and Immunology
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- 巻
- 62
- 号
- 5
- 開始ページ
- 341
- 終了ページ
- 347
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/1348-0421.12590
- 出版者・発行元
- Blackwell Publishing Asia
Treatment of human embryonic lung fibroblast (HEL) cells with tricin (4′, 5, 7-trihydroxy-3′, 5′-dimethoxyflavone) following infection with human cytomegalovirus (HCMV) reportedly significantly suppresses HCMV replication. In the present work, the mechanisms for the anti-HCMV effects of tricin in HEL cells were examined. It was found that exposure of HEL cells to tricin inhibited HCMV replication, with concomitant decreases in amounts of transcripts of the CC chemokine RANTES (CCL5)-encoding gene and in expression of the CCL5 protein. It was also found that transcripts of HCMV immediate early 1 (IE1), and HCMV UL54 (encoding DNA polymerase) and replication of HCMV was significantly lower in CCL5 gene-knockdown cells. These results suggest that the anti-HCMV activity of tricin differs from that of ganciclovir and that CCL5 is one of the chemokines involved in HCMV replication. In addition, it is possible that chemokine CCL5 is one of the targets of tricin.
- ID情報
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- DOI : 10.1111/1348-0421.12590
- ISSN : 1348-0421
- ISSN : 0385-5600
- PubMed ID : 29603339
- SCOPUS ID : 85048041806