2002年5月
Effects of STA(2), a thromboxane A(2) mimetic, in inducing airflow obstruction and airway microvascular leakage in guinea pigs
PHARMACOLOGY
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- 巻
- 65
- 号
- 2
- 開始ページ
- 62
- 終了ページ
- 68
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1159/000056188
- 出版者・発行元
- KARGER
Background: U-46619, a thromboxane A(2) (TXA(2)) mimetic, is shown to cause airway microvascular leakage, although the effects is weak when comparing with that to induce bronchoconstriction in guinea pigs. Objective: In order to know the airway effect of TXA(2) more accurately, we have examined the effects of STA(2), a TXA(2) mimetic with higher affinity to TXA(2) (TP) receptors than U-46619, to induce airway microvascular leakage and airflow obstruction. Methods: Anesthetized and ventilated guinea pigs were i.v. given STA(2) (3-30 nmol/kg) or U-46619 (3100 nmol/kg) 1 min after i.v. Evans blue dye. STA(2)- and U-46619-induced increases in lung resistance (R-L) was measured for 6 min. The amount of extravasated Evans blue dye in the lower airways was, then, examined as an index of leakage. In selected animals, specific TP receptor antagonists (10 mug/kg S-1452 or 10 mg/kg ONO-3708) were pretreated i.v. Results: Both STA(2) and U-46619 induced significant increases in leakage and airflow obstruction. However, STA(2) induced a slow and significantly less increase in RL but caused a significantly greater increase in extravasation of Evans blue dye compared to U-46619. Specific TP receptor antagonists completely abolished both airway effects induced by STA(2) and U46619. Conclusion: Our present results have supported a possibility that TXA(2) induces microvascular leakage as well as bronchoconstriction in the airways. Copyright (C) 2002 S. Karger AG, Basel.
- リンク情報
- ID情報
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- DOI : 10.1159/000056188
- ISSN : 0031-7012
- Web of Science ID : WOS:000175590200002