Hirokazu Hara

Profile Information

Affiliation: Gifu Pharmaceutical University

Degree: Ph.D.(Gifu Pharmaceutical University)

J-GLOBAL ID: 200901074443189280
researchmap Member ID: 1000261129

Research Interests

Research Areas

Life sciences / Pharmaceuticals - health and biochemistry /

Research History

Apr, 2021

Gifu Pharmaceutical University
2007 - Mar, 2021

Gifu Pharmaceutical University
2005 - 2007

Gifu Pharmaceutical University
1998 - 2005

Gifu Pharmaceutical University
2002 - 2003

University of Pittsburgh
2002 - 2003

University of Pittsburgh, Research associate
1994 - 1998

塩野義製薬(株) 研究員
1994 - 1998

Shionogi Co.Ltd., Researcher

Education

Awards

Jul, 2006

平成18年度日本薬学会東海支部学術奨励賞

原宏和

Papers

Inhibition of glutamine metabolism increases sensitivity to plasma-activated medium-induced cytotoxicity.

Shu Tanaka, Sae Hayashi, Tomohiro Otsuka, Tetsuro Kamiya, Kenji Ishikawa, Hirokazu Hara

Free radical research, 1-10, Mar 21, 2024
Royal jelly fatty acids downregulate ANGPTL8 expression through the decrease in HNF4α protein in human hepatoma HepG2 cells.

Yuki Inoue, Marina Ienaga, Tetsuro Kamiya, Tetsuo Adachi, Mitsuhiro Ohta, Hirokazu Hara

Bioscience, biotechnology, and biochemistry, 86(6) 747-754, May 24, 2022
Two new methoxylated flavones isolated from Casimiroa edulis La Llave and their MMP-9 inhibitory activity.

Manami Haba, Naohito Abe, Tetsuro Kamiya, Nagisa Mizuno, Satoshi Okubo, Takao Yamaura, Hirokazu Hara, Masayoshi Oyama

Natural product research, 1-8, Mar 4, 2022 Peer-reviewed
Combined action of FOXO1 and superoxide dismutase 3 promotes MDA-MB-231 cell migration.

Tetsuro Kamiya, Yuji Yamaguchi, Manami Oka, Hirokazu Hara

Free radical research, 56(1) 106-114, Jan, 2022
Regulation of lysyl oxidase expression in THP‐1 cell‐derived M2‐like macrophages

Ryuhei Takemoto, Tetsuro Kamiya, Taku Atobe, Hirokazu Hara, Tetsuo Adachi

Journal of Cellular Biochemistry, 122(8) 777-786, Aug, 2021 Peer-reviewed
6-Hydroxydopamine disrupts cellular copper homeostasis in human neuroblastoma SH-SY5Y cells

Mao Kondo, Hirokazu Hara, Fuka Kamijo, Tetsuro Kamiya, Tetsuo Adachi

Metallomics, 13(7), Jul 12, 2021 Peer-reviewed
Hyperthermia synergistically enhances cancer cell death by plasma-activated acetated Ringer's solution.

Rika Ishii, Tetsuro Kamiya, Hirokazu Hara, Tetsuo Adachi

Archives of biochemistry and biophysics, 693 108565-108565, Aug 29, 2020 Peer-reviewed
Lysyl oxidase expression is regulated by the H3K27 demethylase Jmjd3 in tumor-associated M2-like macrophages.

Ryuhei Takemoto, Tetsuro Kamiya, Hirokazu Hara, Tetsuo Adachi

Journal of clinical biochemistry and nutrition, 66(2) 110-115, Mar, 2020 Peer-reviewed
Ability of plasma-activated acetated Ringer’s solution to induce A549 cell injury is enhanced by a pre-treatment with histone deacetylase inhibitors

Tetsuo Adachi, Yumiko Matsuda, Rika Ishii, Tetsuro Kamiya, Hirokazu Hara

Journal of Clinical Biochemistry and Nutrition, 67(3) 232-239, 2020 Peer-reviewed
Hydrogen sulfide increases copper-dependent neurotoxicity via intracellular copper accumulation

Norika Goto, Hirokazu Hara, Mao Kondo, Naomi Yasuda, Tetsuro Kamiya, Kensuke Okuda, Tetsuo Adachi

Metallomics, 12 in press, 2020 Peer-reviewed
Inhibition of NAMPT markedly enhances plasma-activated medium-induced cell death in human breast cancer MDA-MB-231 cells.

Nagaya M, Hara H, Kamiya T, Adachi T

Archives of biochemistry and biophysics, 676 108155, Oct, 2019 Peer-reviewed
Sublethal treatment with plasma-activated medium induces senescence-like growth arrest of A549 cells: involvement of intracellular mobile zinc.

Hara H, Kobayashi M, Shiiba M, Kamiya T, Adachi T

Journal of clinical biochemistry and nutrition, 65(1) 16-22, Jul, 2019 Peer-reviewed
Inhibitory effects of 4-hydroperoxy-2-decenoic acid ethyl ester on phorbol ester- and TGF-β1-induced MMPs expression

Testuro Kamiya, Miho Tanaka, Hirokazu Hara, Eiji Yamaguchi, Akichika Itoh, Tetsuro Adachi

Free Radical Research, 2019 Peer-reviewed
Enhanced ability of plasma-activated lactated Ringer's solution to induce A549 cell injury.

Matsuzaki T, Kano A, Kamiya T, Hara H, Adachi T

Archives of biochemistry and biophysics, 656 19-30, Oct, 2018 Peer-reviewed
Induction of Human-Lung-Cancer-A549-Cell Apoptosis by 4-Hydroperoxy-2-decenoic Acid Ethyl Ester through Intracellular ROS Accumulation and the Induction of Proapoptotic CHOP Expression.

Kamiya T, Watanabe M, Hara H, Mitsugi Y, Yamaguchi E, Itoh A, Adachi T

Journal of agricultural and food chemistry, 66(41) 10741-10747, Oct, 2018 Peer-reviewed
The MEF2A and MEF2D function as scaffold proteins that interact with HDAC1 or p300 in SOD3 expression in THP-1 cells

Mari Ichihara, Tetsuro Kamiya, Hirokazu Hara, Tetsuo Adachi

Free Radical Research, 52(7) 799-807, Jul 3, 2018 Peer-reviewed
Non-thermal atmospheric pressure plasma-induced IL-8 expression is regulated via intracellular K+ loss and subsequent ERK activation in human keratinocyte HaCaT cells

Emiri Hotta, Hirokazu Hara, Tetsuro Kamiya, Tetsuo Adachi

Archives of Biochemistry and Biophysics, 644 64-71, Apr 15, 2018 Peer-reviewed
Diaporthols A and B: Bioactive diphenyl ether derivatives from an endophytic fungus Diaporthe sp.

Ken-ichi Nakashima, Junko Tomida, Tetsuro Kamiya, Takao Hirai, Yuji Morita, Hirokazu Hara, Yoshiaki Kawamura, Tetsuo Adachi, Makoto Inoue

Tetrahedron Letters, 59 1212-1215, Mar, 2018 Peer-reviewed
Copper chaperone antioxidant-1, Atox-1, is involved in the induction of SOD3 in THP-1 cells

Tetsuro Kamiya, Kosuke Takeuchi, Saki Fukudome, Hirokazu Hara, Tetsuo Adachi

BioMetals, 31(1) 61-68, Feb 1, 2018 Peer-reviewed
4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways

Yuki Inoue, Hirokazu Hara, Yukari Mitsugi, Eiji Yamaguchi, Tetsuro Kamiya, Akichika Itoh, Tetsuo Adachi

Neurochemistry International, 112 288-296, Jan 1, 2018 Peer-reviewed

Misc.

Chemical constituents in water pepper collected at Nagara-gawa River and their anti-inflammatory activity (Part I)

稲葉旬菜, 木村優希, 原宏和, 神谷哲朗, 足立哲夫, 幅愛実, 阿部尚仁, 大山雅義

日本薬学会年会要旨集(CD-ROM), 140th (Web), 2020
ホワイトサポテ由来フラボノイドによるlysyl oxidase発現抑制作用

神谷哲朗, 跡部卓, 竹本竜平, 原宏和, 幅愛実, 大山雅義, 足立哲夫

日本薬理学雑誌, 154(Supplement), 2019
コショウボク果実によるマトリックスメタロプロテアーゼ活性抑制作用

坂本加奈, 神谷哲朗, 原宏和, 阿部尚仁, 大山雅義, 足立哲夫

日本生化学会大会(Web), 90th, 2017
Crosstalk among ROS, Epigenetics and TPA-Induced EMT in Human Breast Cancer MCF7 Cells

Tetsuro Kamiya, Aki Goto, Hirokazu Hara, Tetsuo Adachi

FREE RADICAL BIOLOGY AND MEDICINE, 76 S128-S128, Nov, 2014
Oxidized Low-Density Lipoprotein Accelerates the Degradation of EC-SOD mRNA during Foam Cell Formation in THP-1 Macrophages

Junya Makino, Miyuki Nii, Tetsuro Kamiya, Hirokazu Hara, Tetsuo Adachi

FREE RADICAL BIOLOGY AND MEDICINE, 76 S50-S50, Nov, 2014
CHALCONE GLYCOSIDES FROM BRASSICA RAPA L. EHIDABENIF AND THEIR SYNTHETIC ANALOGUES INHIBIT LPS-INDUCED NO PRODUCTION.

Masayuki Ninomiya, Ryosuke Mochizuki, Hirokazu Hara, Yoko Nakamura, Mamoru Koketsu

PHARMACEUTICAL BIOLOGY, 50(5) 590-590, May, 2012
The Expression of Extracellular-superoxide Dismutase in 3T3-L1 Adipocytes during Endoplasmic Reticulum Stress

Tetsuro Kamiya, Hirokazu Hara, Naoki Inagaki, Tetsuo Adachi

FREE RADICAL BIOLOGY AND MEDICINE, 49 S131-S132, 2010
Conduct of a PBL Tutorial on "Appropriate Use of Medicines" for First-grade Students and Analysis of Product Presentation Evaluations

ADACHI Tetsuo, TERAMACHI Hitomi, HARA Hirokazu, USUI Shigeyuki, KAMIYA Tetsuro, KUZUYA Yumi, TSUCHIYA Teruo, HIRANO Kazuyuki, NAGAI Hiroichi

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 35(3) 195-201, Mar 10, 2009
サクラランの成分と脂肪細胞分化に与える影響

徳山翔太, 大山雅義, 伊藤哲朗, 飯沼宗和, 神谷哲朗, 原宏和, 足立哲夫, 飯田修

日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集, 19th-2009, 2009
The Expression of Extracellular-Superoxide Dismutase in Rat Retinal Pericytes

Tetsuo Adachi, Kazunari Aida, Tetsuro Kamiya, Hirokazu Hara, Ken-ichi Hosoya, Tetsuya Terasaki, Tsunehiko Ikeda

FREE RADICAL BIOLOGY AND MEDICINE, 47 S85-S85, 2009
20-P3-510 1回生「薬を使う薬学」PBLテュートリアルの実施とプロダクト発表に対する評価の分析(薬学教育(モデル・コアカリキュラム),来るべき時代への道を拓く)

足立哲夫, 寺町ひとみ, 原宏和, 臼井茂之, 神谷哲朗, 葛谷有美, 土屋照雄, 平野和行, 永井博弌

日本医療薬学会年会講演要旨集, 18 364-364, Sep 1, 2008
29-P3-29 アドバンストPBLテュートリアル教育トライアルの実施(薬学教育,社会の期待に応える医療薬学を)

足立哲夫, 酒々井真澄, 直井国子, 神谷哲朗, 原宏和

日本医療薬学会年会講演要旨集, 17 285-285, Sep 1, 2007
The expression of extracellular-superoxide dismutase in COS7 cells during hypoxia

Tetsuo Adachi, Harutaka Yamada, Tetsuro Kamiya, Taisuke Toishi, Hirokazu Hara, Hirokazu Imai

FREE RADICAL BIOLOGY AND MEDICINE, 43 S88-S88, 2007
Increase of antioxidative potential by tert-butylhydroquinone protects against cell death associated with 6-hydroxydopamine-induced oxidative stress in neuroblastoma SH-SY5Y cells

H Hara, M Ohta, K Ohta, S Kuno, T Adachi

MOLECULAR BRAIN RESEARCH, 119(2) 125-131, Nov, 2003
Serum extracellular superoxide dismutase inpatients with type 2 diabetes - Relationship to the development of micro- and macrovascular complications

F Kimura, G Hasegawa, H Obayashi, T Adachi, H Hara, M Ohta, M Fukui, Y Kitagawa, H Park, N Nakamura …

DIABETES CARE, 26(4) 1246-1250, Apr, 2003
TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes

M Nishimura, H Obayashi, Mizuta, I, H Hara, T Adachi, M Ohta, H Tegoshi, M Fukui, G Hasegawa, H Shigeta …

HUMAN IMMUNOLOGY, 64(2) 302-309, Feb, 2003
Apomorphine attenuates 6-hydroxydopamine-induced apoptotic cell death in SH-SY5Y cells

H Hara, M Ohta, K Ohta, S Kuno, T Adachi

REDOX REPORT, 8(4) 193-197, 2003
Serum extracellular superoxide dismutase in patients with type 2 diabetes: relationship to the development of micro- and macrovascular complications

Diabetes Care, 26 1246-1250, 2003
Alteration of cellular phosphorylation state affects vitamin D receptor-mediated CYP3A4 mRNA induction in Caco-2 cells

H Hara, Y Yasunami, T Adachi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 296(1) 182-188, Aug, 2002
The expression of extracellular-superoxide dismutase is increased by lysophosphatidylcholine in human monocytic U937 cells

M Yamamoto, H Hara, T Adachi

ATHEROSCLEROSIS, 163(2) 223-228, Aug, 2002

Professional Memberships

Research Projects

Dysfunction of neuronal cell caused by disruption of intracellular copper homeostasis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Methylation dynamics in redox regulation - Elucidation of the molecular mechanisms of tumor metastasis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Kamiya Tetsuro
Cell function control by plasma induced active particles -Academic foundation for safe plasma medicine-

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

ADACHI tetsuo, ISHIKAWA kenji, TANAKA hiromasa
硫化水素の新規生理機能：金属イオン恒常性破綻による神経細胞傷害に対する保護作用

基盤研究(C), 2017 - 2019

原宏和
Involvement of intracellular copper ion homeostasis in epigenetic redox regulation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Kamiya Tetsuro
Direct intervention of incretin to protect the blood-retinal barrier - Suppression on onset and progression of diabetic retinopathy -

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

ADACHI TETSUO, HARA Hirokazu, KAMIYA Tetsuro, IKEDA Tsunehiko, YASUDA Hiroyuki, MAKINO Junya
プラズマ刺激を感知する細胞機構の解明―プラズマ医療の推進に向けた分子基盤の確立―

基盤研究(C), 2014 - 2016

原宏和
脳梗塞治療薬開発に向けた新戦略－虚血性神経細胞障害における亜鉛シグナルの意義－

基盤研究(C), 2011 - 2013

原宏和
亜鉛制御に基づく新規脳梗塞治療薬の開発に向けた創薬ターゲットの探索

一般財団法人島原科学振興会研究助成金, 2013

原宏和
Contribution of impairment of redox-regulation in development of Intraretinal microvascular abnormalities

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

ADACHI Tetsuo, HARA Hirokazu, KAMIYA Tetsuro, IKEDA Tsunehiko
亜鉛による虚血性神経細胞障害の増悪機序の解明と新規治療薬の開発

基盤研究(C), 2008 - 2009

原宏和
Regulation of anti-arteriosclerotic activity between anti-oxidative enzyme and adipocytokines

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2008

ADACHI Tetsuo, HARA Hirokazu, KAMIYA Tetsuro, YAMADA Harutaka
脳内亜鉛の恒常性破綻に起因する神経細胞障害の分子機構の解明と神経保護物質の探索

基盤研究(C), 2005 - 2006

原宏和
活性酸素種による神経機能制御に関する分子の探索と医薬品開発への応用

岐阜県脳医学研究振興補助金, 2004 - 2005
The medicine that functions to maintain the redox state might to the pathological conditions of insulin resistance

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

ADACHI Tetsuo, HARA Hirokazu, INOUE Minoru
Dysfunction of protection enzymes of vascular endothelial cell surface results in the pathogenesis of cardiovascular disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2001

ADACHI Tetsuo, TASAKI Hiromi, HARA Hirokazu
Application of endothelial cell-binding superoxide dismutase (EC-SOD) on screening of the initiation-progress of renal diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1998 - 1999

ADACHI Tetsuo, YAMADA Harutaka, HARA Hirokazu
Mechanism of neuronal cell death associated with oxidative stress
Mechanism of cytochrome P450 gene induction by xenochemicals

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