2006年
Fluctuation of actin sliding over myosin thick filaments in vitro
2006 IEEE INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE
- ,
- ,
- ,
- 巻
- 1
- 号
- 開始ページ
- 262
- 終了ページ
- +
- 記述言語
- 英語
- 掲載種別
- 研究論文(国際会議プロシーディングス)
- DOI
- 10.2142/biophysics.1.45
- 出版者・発行元
- IEEE
It is customarily assumed that myosin motors act as independent force generators. Here, we tested this assumption by analyzing the fluctuation of the actin sliding movement in vitro over long native thick filaments from shell fish smooth muscle. This analysis is based on the prediction that the effective diffusion coefficient of actin, a measure of the fluctuation, is proportional to the inverse of the number of myosin motors generating the sliding movement of an actin filament, hence proportional to the inverse of the actin length, if the actions of the motors are independent. Contrary to this prediction, we found the effective diffusion coefficient to be independent of the actin length. This result shows that the myosin motors are not independent force generators when generating the continuous sliding movement of actin in vitro.
- リンク情報
- ID情報
-
- DOI : 10.2142/biophysics.1.45
- ISSN : 2474-378X
- eISSN : 2474-3798
- Web of Science ID : WOS:000246216100050