1999年5月
Argyrophilic grains in late-onset Creutzfeld-Jakob diseased brain
PATHOLOGY INTERNATIONAL
- ,
- ,
- 巻
- 49
- 号
- 5
- 開始ページ
- 369
- 終了ページ
- 373
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1046/j.1440-1827.1999.00883.x
- 出版者・発行元
- BLACKWELL SCIENCE ASIA
Braak's argyrophilic grains (ArG) are spindle-shaped structures originally described in patients with dementia. Herein, a unique case of sporadic Creutzfeldt-Jakob disease (CJD) accompanied by numerous ArG is presented, The pathological picture was typical of CJD based on the findings of routine hematoxylin-eosin staining. The highest density of ArG was observed throughout the parahippocampal gyrus and the temporal gyri; however, the sector CA1 of the hippocampus showed less ArG. An immunohistochemical analysis for prion protein (PrP) revealed diffuse fine neuropil staining in the cerebral cortex, while the ArG themselves did not demonstrate any immunoreaction for PrP. No correlation was observed between the densities of ArG and either the presence of senile plaques, neurofibrillary tangles or neuropil threads in the present case. To our knowledge, this is the first report of CJD demonstrating numerous ArG.
- リンク情報
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- DOI
- https://doi.org/10.1046/j.1440-1827.1999.00883.x
- CiNii Articles
- http://ci.nii.ac.jp/naid/10008344466
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10417678
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000081437700001&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1046/j.1440-1827.1999.00883.x
- ISSN : 1320-5463
- CiNii Articles ID : 10008344466
- PubMed ID : 10417678
- Web of Science ID : WOS:000081437700001