MISC

2004年8月

Memory of learning facilitates saccadic adaptation in the monkey

JOURNAL OF NEUROSCIENCE
  • Y Kojima
  • ,
  • Y Iwamoto
  • ,
  • K Yoshida

24
34
開始ページ
7531
終了ページ
7539
記述言語
英語
掲載種別
DOI
10.1523/JNEUROSCI.1741-04.2004
出版者・発行元
SOC NEUROSCIENCE

A motor learning mechanism called saccadic adaptation ensures accuracy of saccades throughout life despite growth, aging, and some pathologies of the oculomotor plant or nervous system. The present study investigates effects of preceding adaptation on the speed of subsequent adaptation during single experiments. Adaptive changes in gain ( movement size divided by target eccentricity) were induced by intrasaccadic step (ISS) of the target. After the gain was altered ( control block), we reversed the direction of ISS to bring the gain back to similar to1.0 ( recovery). We then reversed ISS direction again to induce another adaptation ( test block). Analyses revealed that the gain changed at a higher rate in the early part of test adaptation than in the corresponding part of control. After similar to 100 - 300 saccades in the test block, adaptation slowed down. The gain value at which adaptation slowed was correlated with the gain achieved in the control. We further examined effects of a 30 min intervention inserted between recovery and test blocks. When zero-visual-error trials ( similar to 700 saccades) were repeated during this period, the rate of test adaptation was similar to that of control. In contrast, when the animal was deprived of visual inputs during this period, test adaptation was still influenced by preceding learning. We conclude that a memory of previous learning remains during recovery to facilitate subsequent adaptation and that such a memory does not disappear merely with time but is erased actively by repeated zero-error movements. Our results, which cannot be explained by a single mechanism, suggest that the saccadic system is equipped with more than one plasticity process.

Web of Science ® 被引用回数 : 98

リンク情報
DOI
https://doi.org/10.1523/JNEUROSCI.1741-04.2004
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000223521200013&DestApp=WOS_CPL

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