2013年9月
In vitro responses of neurofibroma fibroblasts, mast cells and Schwann cells obtained from patients with neurofibromatosis 1 to 308-nm excimer light and/or vitamin D3
Journal of Dermatology
- ,
- ,
- 巻
- 40
- 号
- 9
- 開始ページ
- 743
- 終了ページ
- 745
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/1346-8138.12242
Fibroblasts, mast cells and Schwann cells were isolated from neurofibromas of patients with neurofibromatosis 1, and their responses to 308-nm excimer light irradiation and/or vitamin D3 or an analog (tacalcitol
1,24-dihydroxyvitamin D3) were examined in vitro. Excimer light irradiation (300 mJ/cm2) suppressed the growth of all three cell types. Exposure to 10-7 mol/L of 1α,25(OH)2D 3 (VD3) or tacalcitol suppressed the growth of fibroblasts and mast cells, but not Schwann cells. These results suggest that the different neurofibroma cell types show different responses to VD3. A combination of excimer light irradiation and VD3 is necessary to suppress the growth of neurofibroma cells in vivo. © 2013 Japanese Dermatological Association.
1,24-dihydroxyvitamin D3) were examined in vitro. Excimer light irradiation (300 mJ/cm2) suppressed the growth of all three cell types. Exposure to 10-7 mol/L of 1α,25(OH)2D 3 (VD3) or tacalcitol suppressed the growth of fibroblasts and mast cells, but not Schwann cells. These results suggest that the different neurofibroma cell types show different responses to VD3. A combination of excimer light irradiation and VD3 is necessary to suppress the growth of neurofibroma cells in vivo. © 2013 Japanese Dermatological Association.
- ID情報
-
- DOI : 10.1111/1346-8138.12242
- ISSN : 0385-2407
- ISSN : 1346-8138
- PubMed ID : 23855960
- SCOPUS ID : 84883557324