Hiroshi Okamoto - My portal

Profile Information

Affiliation: Professor Emeritus, Graduate School of Medicine Medical Sciences, Tohoku University

J-GLOBAL ID: 200901007115758309
researchmap Member ID: 1000003935

External link: http://db.tohoku.ac.jp/whois/e_detail/f3431c410316984fa67d7813d3feba70.html

Research Interests

Research Areas

Education

- Mar, 1969

生理系, Graduate School, Division of Medicine, Kyoto University
- Mar, 1964

医学科, Faculty of Medicine, Kanazawa University

Awards

Papers

179

Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells

Haruhiro Higashida, Sarah E. H. Bowden, Shigeru Yokoyama, Alla Salmina, Minako Hashii, Naoto Hoshi, Jia-Sheng Zhang, Rimma Knijnik, Mami Noda, Zen-Guo Zhong …

NEUROSCIENCE RESEARCH, 57(3) 339-346, Mar, 2007 Peer-reviewed
CD38 is critical for social behaviour by regulating oxytocin secretion

Duo Jin, Hong-Xiang Liu, Hirokazu Hirai, Takashi Torashima, Taku Nagai, Olga Lopatina, Natalia A. Shnayder, Kiyofumi Yamada, Mami Noda, Toshihiro Seike …

NATURE, 446(7131) 41-45, Mar, 2007 Peer-reviewed
Reg I-knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine

T. Ose, Y. Kadowaki, H. Fukuhara, H. Kazumori, S. Ishihara, J. Udagawa, H. Otani, S. Takasawa, H. Okamoto, Y. Kinoshita

ONCOGENE, 26(3) 349-359, Jan, 2007 Peer-reviewed
REG I expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy

Satoru Motoyama, Toshihiro Sugiyama, Yasuharu Ueno, Hiroshi Okamoto, Shin Takasawa, Hiroshi Nanjo, Hitoshi Watanabe, Kiyotomi Maruyama, Manabu Okuyama, Jun-ichi Ogawa

ANNALS OF SURGICAL ONCOLOGY, 13(12) 1724-1731, Dec, 2006 Peer-reviewed
Reg (regenerating) gene overexpression in islets from non-obese diabetic mice with accelerated diabetes: role of IFN beta

R. Planas, A. Alba, J. Carrillo, M. C. Puertas, R. Ampudia, X. Pastor, H. Okamoto, S. Takasawa, W. Gurr, R. Pujol-Borrell …

DIABETOLOGIA, 49(10) 2379-2387, Oct, 2006 Peer-reviewed
RAGE control of diabetic nephropathy in a mouse model - Effects of RAGE gene disruption and administration of low-molecular weight heparin

Khin-Mar Myint, Yasuhiko Yamamoto, Toshio Doi, Ichiro Kato, Ai Harashima, Hideto Yonekura, Takuo Watanabe, Harumichi Shinohara, Masayoshi Takeuchi, Koichi Tsuneyama …

DIABETES, 55(9) 2510-2522, Sep, 2006 Peer-reviewed
Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas

YR Lu, A Ponton, H Okamoto, S Takasawa, PL Herrera, JL Liu

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 291(1) E50-E58, Jul, 2006 Peer-reviewed
Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis

Martin H. Bluth, Sameer A. Patel, Brian K. Dieckgraefe, Hiroshi Okamoto, Michael E. Zenilman

WORLD JOURNAL OF GASTROENTEROLOGY, 12(28) 4511-4516, Jul, 2006 Peer-reviewed
Identification of mouse orthologue of endogenous secretory receptor for advanced glycation end-products: structure, function and expression

A Harashima, Y Yamamoto, CM Cheng, K Tsuneyama, KM Myint, A Takeuchi, K Yoshimura, H Li, T Watanabe, S Takasawa …

BIOCHEMICAL JOURNAL, 396(1) 109-115, May, 2006 Peer-reviewed
A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice

R Inagi, Y Yamamoto, M Nangaku, N Usuda, H Okamato, K Kurokawa, CV de Strihou, H Yamamoto, T Miyata

DIABETES, 55(2) 356-366, Feb, 2006 Peer-reviewed
Cyclin D1 activation through ATF-2 in reg-induced pancreatic beta-cell regeneration

S Takasawa, T Ikeda, T Akiyama, K Nata, K Nakagawa, NJ Shervani, N Noguchi, S Murakami-Kawaguchi, A Yamauchi, Takahashi, I …

FEBS LETTERS, 580(2) 585-591, Jan, 2006 Peer-reviewed
Interleukin-8 regulates expression of reg protein in Helicobacter pylori-infected gastric mucosa

N Yoshino, S Ishihara, MAK Rumi, CF Ortega-Cava, T Yuki, H Kazumori, S Takazawa, H Okamoto, Y Kadowaki, Y Kinoshita

AMERICAN JOURNAL OF GASTROENTEROLOGY, 100(10) 2157-2166, Oct, 2005 Peer-reviewed
Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6

T Nakazawa, S Takasawa, N Noguchi, K Nata, A Tohgo, M Mori, K Nakagawara, T Akiyama, T Ikeda, A Yamauchi …

GENE, 360(1) 55-64, Oct, 2005 Peer-reviewed
Activation of regenerating gene Reg in rat and human hearts in response to acute stress

T Kiji, Y Dohi, S Takasawa, H Okamoto, A Nonomura, S Taniguchi

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 289(1) H277-H284, Jul, 2005 Peer-reviewed
Receptor for advanced glycation end products is a promising target of diabetic nephropathy.

Yamamoto Yasuhiko, Doi Toshio, Kato Ichiro, Shinohara Harumichi, Sakurai Shigeru, Yonekura Hideto, Watanabe Takuo, Myint Kihn Mar, Harashima Ai, Takeuchi Masayoshi …

Ann N Y Acad Sci, 1043 562-566, Jun, 2005 Peer-reviewed
Expression of Reg/PAP family members during motor nerve regeneration in rat

K Namikawa, M Fukushima, K Murakami, A Suzuki, S Takasawa, H Okamoto, H Kiyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 332(1) 126-134, Jun, 2005 Peer-reviewed
Identification of islet-type ryanodine receptor and its cyclic ADP-ribose-induced intracellular Ca2+ mobilization.

Takasawa Shin, Nata Koji, Noguchi Naoya, Ikeda Takayuki, Yamauchi Akiyo, Takahashi Iwao, Yoshikawa Takeo, Okamoto Hiroshi

Diabetes, 54 A406-A406, Apr, 2005 Peer-reviewed
Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III.

Nata Koji, Ikeda Takayuki, Noguchi Naoya, Yamauchi Akiyo, Takahashi Iwao, Yoshikawa Takeo, Onogawa Tohru, Takasawa Shin, Okamoto Hiroshi

Diabetes, 54 A392-A392, Apr, 2005 Peer-reviewed
Pancreatic Beta-cell regeneration by Regenerating gene (Reg) and a possible therapeutic use of Reg gene and/or Reg protein in diabetes treatment.

Okamoto Hiroshi, Takasawa Shin, Nata Koji, Noguchi Naoya, Ikeda Takayuki, Yamauchi Akiyo, Takahashi Iwao, Yoshikawa Takeo

Int J Artificial Organs, 28(4) 329-330, Apr, 2005 Peer-reviewed
REG I alpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer

A Sekikawa, H Fukui, S Fujii, J Takeda, A Nanakin, H Hisatsune, H Seno, S Takasawa, H Okamoto, T Fujimori …

GASTROENTEROLOGY, 128(3) 642-653, Mar, 2005 Peer-reviewed

Misc.

Recent advances in physiological and pathological significance of NAD(+) metabolites: roles of poly(ADP-ribose) and cyclic ADP-ribose in insulin secretion and diabetogenesis. (Nutrition Research Reviews)

Okamoto H, Takasawa S

Nutrition Research Reviews, 16(2) 253-266, Apr, 2003
Recent advances in physiological and pathological significance of tryptophan-NAD+ metabolites: lessons from insulin-producing pancreatic beta-cells. (Adv Exp Med Biol)

Okamoto Hiroshi

Adv Exp Med Biol, 527 243-252, Apr, 2003
Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in beta-cells. (Diabetes)

Okamoto Hiroshi, Takasawa Shin

Diabetes, 51 Suppl 3 S462-73, Dec, 2002
Pancreatic β-cell death, regeneration and insulin secretion: Roles of poly(ADP-ribose) polymerase and cyclic ADP-ribose

Shin Takasawa, Hiroshi Okamoto

International Journal of Experimental Diabetes Research, 3(2) 79-96, 2002
Physiological and pathological significance of the CD38-cyclic ADP-ribose signaling system. (Chem Immunol)

Okamoto H, Takasawa S, Nata K, Kato I, Tohgo A, Noguchi N

Chem Immunol, 75 121-145, Apr, 2000
The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic beta-cells. (J Hepatobiliary Pancreat Surg)

Okamoto H

J Hepatobiliary Pancreat Surg, 6(3) 254-262, Apr, 1999
The CD38-cyclic ADP-ribose signaling system in insulin secretion. (Mol Cell Biochem)

Okamoto H

Mol Cell Biochem, 193(1月2日) 115-118, Mar, 1999
Cyclic ADP-ribose-mediated insulin secretion and Reg, regenerating gene. (J Mol Med)

Okamoto H

J Mol Med, 77(1) 74-78, Jan, 1999
The CD38-cyclic ADP-ribose signalling system in insulin secretion: molecular basis and clinical implications. (Diabetologia)

Okamoto H, Takasawa S, Nata K

Diabetologia, 40(12) 1485-1491, Dec, 1997
Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38: inhibition of hydrolysis by ATP and physiological significance. (Methods Enzymol)

Okamoto H, Takasawa S, Tohgo A, Nata K, Kato I, Noguchi N

Methods Enzymol, 280 306-318, Apr, 1997
New aspects to the functioning and regeneration of pancreatic beta-cells. Cyclic ADP-ribose and Reg gene. (Adv Exp Med Biol)

Okamoto H

Adv Exp Med Biol, 426 301-311, Apr, 1997
New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose. (Biochimie)

Okamoto H, Takasawa S, Tohgo A

Biochimie, 77(5) 356-363, Apr, 1995
Islet beta-cell regeneration and reg genes. (Adv Exp Med Biol)

Unno M, Itoh T, Watanabe T, Miyashita H, Moriizumi S, Teraoka H, Yonekura H, Okamoto H

Adv Exp Med Biol, 321 61-66, Apr, 1992
[reg (regenerating gene) : structure and tissue specific expression] (Nippon Rinsho)

Yonekura H, Watanabe T, Terazono K, Yamamoto H, Okamoto H, Yonemura Y, Itoh T, Tsuzuki H, Teraoka H, Yoshida N

Nippon Rinsho, 49 Suppl 752-759, Feb, 1991
Complete nucleotide sequence of human vasoactive intestinal peptide/PHM-27 gene and its inducible promoter. (Ann N Y Acad Sci)

Yamagami T, Ohsawa K, Nishizawa M, Inoue C, Gotoh E, Yanaihara N, Yamamoto H, Okamoto H

Ann N Y Acad Sci, 527 87-102, Apr, 1988
The role of poly(ADP-ribose) synthetase in the development of insulin-dependent diabetes and islet B-cell regeneration. (Biomed Biochim Acta)

Okamoto H

Biomed Biochim Acta, 44(1) 15-20, Apr, 1985
MOLECULAR-BASIS OF EXPERIMENTAL DIABETES - DEGENERATION, ONCOGENESIS AND REGENERATION OF PANCREATIC B-CELLS OF ISLETS OF LANGERHANS (Bioessays)

Okamoto H

Bioessays, 2(1) 15-21, Jan, 1985
[Vasoactive intestinal polypeptide(VIP)- and insulin-producing cells--molecular biology, physiology and pathology] (Nippon Naibunpi Gakkai Zasshi)

Okamoto H

Nippon Naibunpi Gakkai Zasshi, 60(12) 1449-1463, Dec 20, 1984
Regulation of proinsulin synthesis in pancreatic islets and a new aspect to insulin-dependent diabetes. (Mol Cell Biochem)

Okamoto H

Mol Cell Biochem, 37(1) 43-61, Jun 9, 1981

Professional Memberships

日本学術会議(2005/10-)