Apr, 2005
Kinetic study of the mechanism of free-radical scavenging action in curcumin: Effects of solvent and pH
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
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- Volume
- 78
- Number
- 4
- First page
- 615
- Last page
- 621
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1246/bcsj.78.615
- Publisher
- CHEMICAL SOC JAPAN
A kinetic Study was performed for the free-radical scavenging actions of curcumin and half-curcumin, which has a half-structure of curcumin, in order to clarify the mechanism of free-radical-scavenging in curcumin. The second-order rate constants for radical-scavenging reactions of curcumin and half-curcumin were measured by a stopped-flow spectrophotometer in several organic solvents (methanol, ethanol, acetonitrile, chloroform, and benzene) and in aqueous Triton X-100 (5.0 wt %) micelle solutions at various pH. The difference in the rate constant and solvent dependence between curcumin and half-curcumin suggests that the enol structure with the intramolecular hydrogen-bond Of Curcumin strongly enhances the radical-scavenging activity. Furthermore, notable pH dependences were observed for the rate constants of curcumin and half-curcumin in micelle solutions, suggesting that the acid-base dissociation equilibrium of phenol-protons in curcumin and half-curcumin affects their radical-scavenging activities.
- Link information
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- DOI
- https://doi.org/10.1246/bcsj.78.615
- CiNii Articles
- http://ci.nii.ac.jp/naid/10015463342
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000228912900008&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=18744403061&origin=inward
- ID information
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- DOI : 10.1246/bcsj.78.615
- ISSN : 0009-2673
- eISSN : 1348-0634
- CiNii Articles ID : 10015463342
- SCOPUS ID : 18744403061
- Web of Science ID : WOS:000228912900008