Precise mass measurements of short-lived exotic nuclei are very important for the understanding of basic nuclear structure physics and astrophysical nucleosynthesis in nature, as well as for the test and the development of theoretical nuclear mass models. At GSI, the Isochronous Mass Spectrometry (IMS) dedicated to mass measurements of short-lived nuclides was developed. In this contribution, the IMS technique is briefly reviewed. Recently, the first large-scale measurement on the (238)U fission fragment was done successfully. The measured mass values are in excellent agreement with the recent Penning trap data, however, they show a systematical deviation from the values in the latest atomic mass evaluation. Some representative results from this experiment will be presented, including their impact on nuclear structure physics and astrophysical r-process nucleosynthesis.