論文

査読有り
2007年1月

Difference in production of infectious wild-type measles and vaccine viruses in monocyte-derived dendritic cells

VIRUS RESEARCH
  • Kaori Ohgimoto
  • ,
  • Shinji Ohgimoto
  • ,
  • Toshiaki Ihara
  • ,
  • Hiroyuki Mizuta
  • ,
  • Satoshi Ishido
  • ,
  • Minoru Ayata
  • ,
  • Hisashi Ogura
  • ,
  • Hak Hotta

123
1
開始ページ
1
終了ページ
8
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.virusres.2006.07.006
出版者・発行元
ELSEVIER SCIENCE BV

Macrophages (Mo) and dendritic cells (DC) are thought to be targets of measles virus (MeV) at the early stage of infection. We compared the growth of Edmonston-derived vaccine strains and fresh clinical isolates of MeV in monocytes, monocyte-derived granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced Mo (GM-MO) and in monocyte-derived DC (Mo-DC). Neither vaccine strains nor fresh isolates thrived in monocytes and GM-Mo and no differences were evident among them. On the other hand, infectious virus production was robust in Mo-DC infected with fresh isolates, but below the limits of detection in those infected with vaccine strains. Although the vaccine strains infected Mo-DC and replicated comparably with the fresh isolates, they accumulated far less matrix (M) protein. This was attributed to a difference in the stability of M protein produced in Mo-DC between the strains. Impaired production of infectious viruses in DC may be one cause of vaccine strain attenuation. (c) 2006 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 15

リンク情報
DOI
https://doi.org/10.1016/j.virusres.2006.07.006
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16959355
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000243743900001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.virusres.2006.07.006
  • ISSN : 0168-1702
  • PubMed ID : 16959355
  • Web of Science ID : WOS:000243743900001

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