1997年8月
Positive correlation between levels of IL-1 or IL-2 and 1,25(OH)(2)D/25OH-D ratio in synovial fluid of patients with rheumatoid arthritis
LIFE SCIENCES
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- 巻
- 61
- 号
- 10
- 開始ページ
- 977
- 終了ページ
- 985
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0024-3205(97)00602-4
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
The present study determined the levels in synovial fluid (SF) of vitamin D metabolites (1,25-dihydroxyvitamin D (1,25(OH)(2)D), 24,25-dihydroxyvitamin D (24,25(OH)(2)D) and 25-hydroxyvitamin D (25-OH-D)), and of the cytokines. We evaluated SF from 21 patients with rheumatoid arthritis (RA) and 6 patients with osteoarthritis (OA). The levels of vitamin D metabolites in SF, as determined by two different extraction methods, were significantly correlated (p < 0.05, n=7). The levels of 3 vitamin D metabolites were significantly higher in the RA SF than in OA SF (p < 0.05). The ratio of 1,25(OH)(2)D/25-OH-D in RA SF, which is presumed to reflect the activity of 25-OH-D-1-hydroxylase (1-OH-ase), was positively correlated with the levels of interleukin-1 alpha (IL-1 alpha), IL-1 beta, and IL-2 in such SF, and was significantly higher than that in sera from RA patients. This suggests an important role for these cytokines in the activation of 1-OH-ase in RA synovium. The ratio of 24,25(OH)(2)D/25-OH-D, which is presumed to reflect 25-OH-D-24-hydroxylase (24-OH-ase) activity, was significantly correlated with 1,25(OH)(2)D levels only in RA SF, but not in sera from RA patients, suggesting a local regulation of vitamin D metabolism that 1,25-(OH)(2)D induces 24-OH-ase as in other target cells. Our observations suggested that 1,25(OH)(2)D and 24,25(OH)(?)2D are produced locally from 25-OH-D in RA synovium, and that the syntheses of 1,25(OH)(2)D and 24,25(OH)(2)D may be affected by IL-1/IL-2 and 1,25(OH)(2)D in RA SF, respectively.
- リンク情報
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- DOI
- https://doi.org/10.1016/S0024-3205(97)00602-4
- CiNii Articles
- http://ci.nii.ac.jp/naid/80009819088
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/9296336
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1997XQ84500005&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/S0024-3205(97)00602-4
- ISSN : 0024-3205
- CiNii Articles ID : 80009819088
- PubMed ID : 9296336
- Web of Science ID : WOS:A1997XQ84500005