2016年4月
Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition
FEBS LETTERS
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- 巻
- 590
- 号
- 8
- 開始ページ
- 1211
- 終了ページ
- 1221
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/1873-3468.12147
- 出版者・発行元
- WILEY-BLACKWELL
Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12-21 amplicon, which contains ERBB2. We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial-to-mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2.
- リンク情報
- ID情報
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- DOI : 10.1002/1873-3468.12147
- ISSN : 0014-5793
- eISSN : 1873-3468
- Web of Science ID : WOS:000375008700018