Takeomi Murata - My portal

Profile Information

Affiliation: Associate Professor, Faculty of Agriculture - Department of Applied Life Sciences, Shizuoka University

Degree: 博士(農学)(Mar, 1998, 岐阜大学)
農学修士(Mar, 1989, 静岡大学)

J-GLOBAL ID: 200901042174231586
researchmap Member ID: 1000185552

Research Interests

Research Areas

Life sciences / Applied biochemistry /

Education

- 1989

Shizuoka University
- 1989

Graduate School, Division of Agriculture, Shizuoka University
- 1987

Faculty of Agriculture, Shizuoka University
- 1987

Faculty of Agriculture, Shizuoka University

Committee Memberships

Apr, 2007 - Present

Journal of Applied Glycoscience
Apr, 2010 - Mar, 2011

財団法人杉山報公会
Apr, 2008 - Mar, 2009

財団法人杉山報公会

Awards

Mar, 2005

農芸化学奨励賞 (課題名：糖鎖ライブラリーを活用した分子認識プローブの構築に関する研究)

Papers

Binding of Galectin-3, a beta-Galactoside-binding Lectin, to MUC1 Protein Enhances Phosphorylation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) and Akt, Promoting Tumor Cell Malignancy

Yugo Mori, Kaoru Akita, Masakazu Yashiro, Tetsuji Sawada, Kosei Hirakawa, Takeomi Murata, Hiroshi Nakada

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(43) 26125-26140, Oct, 2015 Peer-reviewed
Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients.

責任著者]Y. Watanabe, 共著者]T.Murata

mBio, 6(2) 1-15, Feb, 2015 Peer-reviewed
Materials science and engineering of mucin: A new aspect of mucin chemistry

Kiminori Ushida, Takeomi Murata

Studies in Natural Products Chemistry, 39 115-159, 2013 Peer-reviewed
Mannose-specific lectin from the mushroom Hygrophorus russula

責任著者]Kawagishi, H, 共著者]Suzuki, T, Sugiyama, K, Hirai, H, Ito, H, Murata, T

Glycobiology, 22 616-629, Apr, 2012 Peer-reviewed
Design and synthesis of high-avidity tetravalent glycoclusters as probes for Sambucus sieboldiana agglutinin and characterization of their binding properties

責任著者]Usui, T, 共著者]Ogata, M, Yano, M, memura, S, Murata, T, Park, E. Y

Glycoconjugate. Chem, 23 97-105, Apr, 2012 Peer-reviewed
Immunomodulation of monocyte-derived dendritic cells through ligation of tumor-produced mucins to Siglec-9

責任著者]Nakada H, 共著者]Ohta M, Ishida A, Toda M, Inoue M, Murata T

Biochem. Biophys. Res. Commun., 402((num)) 663-669, Jan, 2010 Peer-reviewed
Toxic isolectins from the mushroom Boletus venenatus

責任著者]Horibe, 共著者]M, Kobayashi,Y, Dohra,H, Morita,T, Murata,T, Usui,T, Hirabayashi,J, Matsuura,M, Yamada,M …

PHYTOCHEMISTRY, 71(71) 648-657, Jan 1, 2010 Peer-reviewed
Kinetic studies on endo-β-galactosidase by a novel colorimetric assay and synthesis of N-acetyllactosamine-repeating oligosaccharide β-glycosides using its transglycosylation activity.

責任著者]Murata, 共著者]T, Hattori,T, Amarume,S, Koichi,A, Usui,T

EUROPEAN JOURNAL OF BIOCHEMISTRY, 270 3709-3719, Oct, 2003 Peer-reviewed
Chemoenzymatic synthesis and application of glycopolymers containing multivalent sialyloligosaccharides with a poly (L-glutamic acid) backbone for inhibition of infection by influenza viruses

責任著者]Totani, 共著者]K, Kubota,T, Kuroda,T, Murata,T, Hidari,K, Suzuki,T, Suzuki,Y, Kobayashi,K, Ashida,H …

GLYCOBIOLOGY, 13 315-326, Jan, 2003 Peer-reviewed
Enzymatic synthesis of sulfated disaccharides using b-D-galactosidase-catalyzed transglycosylation.

責任著者]Murata, 共著者]T, Kosugi,M, Nakamura,T, Urashima,T, Usui,T

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 65 2456-2464, Jan, 2001 Peer-reviewed
Regioselective synthesis of ρ-nitrophenyl glycosides of β-D-galactopyranosyl-disaccharide by use of transglycosylation of β-D-galactosidase

責任著者]Zeng, 共著者]X, Yoshino,R, Murata,T, Ajisaka,K, Usui,T

Carbohydrate Research, 325 120-131, Jan, 2000 Peer-reviewed
Chemoenzymatic synthesis of glycopolypeptides carrying α-Neu5Ac-(2→3)-β-D-Gal-(1→3)-α-D-GalNAc, β-D-Gal-(1→3)-α-D-GalNAc, and related componnds and analysis of their specific interactions with lectin

責任著者]Zeng X, 共著者]Nakaaki,Y, Murata,T, Usui,T

Archives of Biochemistry and Biophysics, 383, Jan, 2000 Peer-reviewed
Facile enzymatic conversion of lactose into lacto-N-tetraose and lacto-N-neoletraose. (共著)

責任著者]Murata, 共著者]T, Inukai,T, Suzuki,M, Usui,T

Clycoconjugate Journal, 16(3) 195-195, Jan, 1999 Peer-reviewed
Enzymatic synthesis of α-L-fucosyl N-acelyllactosamine and α-L-fucosyllactoses. (共著)

責任著者]Murata, 共著者]T, Morimoto,S, Watanabe,S, Zeng,X, Usui,T

Carbohydrate Research, 320(2-3) 192, Jan, 1999 Peer-reviewed

Misc.

Molecular design of N-linked tetravalent glycosides bearing N-acetylglucosamine, N,N '-diacetylchitobiose and N-acetyllactosamine: Analysis of cross-linking activities with WGA and ECA lectins

Ryuichi Masaka, Makoto Ogata, Yoshinori Misawa, Megumi Yano, Chika Hashimoto, Takeomi Murata, Hirokazu Kawagishi, Taichi Usui

BIOORGANIC & MEDICINAL CHEMISTRY, 18(2) 621-629, Jan, 2010
Chemoenzymatic synthesis of glycan-arrayed polymeric inhibitors against influenza infection.

責任著者]Ogata M, 共著者]Murata T, Park,E-Y, Usui T

JOURNAL OF APPLIED GLYCOSCIENCE, (57) 137-144, Jan 1, 2010
Immunomodulation of monocyte-derived dendritic cells through ligation of tumor-produced mucins to Siglec-9.

責任著者]Ohta M, 共著者]Ishida A, Toda M, Akita K, Inoue M, Yamashita K, Watanabe M, Murata T, Usui T, Nakada H

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (402) 663-669, Jan, 2010
Toxic isolectins from the mushroom Boletus venenatus

責任著者]Horibe, 共著者]M, Kobayashi,Y, Dohra,H, Morita,T, Murata,T, Usui,T, Hirabayashi,J, Matsuura,M, Yamada,M …

PHYTOCHEMISTRY, 71(71) 648-657, Jan, 2010 Peer-reviewed
Chemoenzymatic synthesis of glycan-arrayed polymeric inhibitors against influenza infection.

責任著者]Ogata M, 共著者]Murata T, Park,E-Y, Usui T

JOURNAL OF APPLIED GLYCOSCIENCE, 57(57) 137-144, Jan, 2010
Molecular design of fluorescent labeled glycosides as acceptor substrates for sialyltransferases

Makoto Ogata, Takakiyo Obara, Yasushi Chuma, Takeomi Murata, Enoch Y. Park, Taichi Usui

Bioscience, Biotechnology and Biochemistry, 74(11) 2287-2292, 2010
Enzymatic synthesis of spacer-linked divalent glycosides carrying N-acetylglucosamine and N-acetyllacrosamine: Analysis crosse-linked activity with WGA.

責任著者]Misawa, 共著者]Y, Akimoto,T, Amarure,S, Murata T, Uusi T

JOURNAL OF BIOCHEMISTRY, 143(143) 21-30, Jan, 2008
Mucin-induced apoptosis of monocyte-derived dendritic cells during maturation.

責任著者]Ishida, 共著者]A, Ohta,M, Toda,M, Murata,T, Usui,T, Akita,K, Inoue,M, Nakada,H

PROTEOMICS, (8) 3342-3349, Jan, 2008
Efficient synthesis of spacer-N-linked double-headed glycosides carrying N-acetylglucosamine and N,N′-diacetylchitobiose and their cross-linking activities with wheat germ agglutinin.

責任著者]Y. Misawa, 共著者]R. Masaka, K. Maeda, M. Yano,T. Murata, H. Kawagishi, T. Usui

CARBOHYDRATE RESEARCH, 343(343) 434-442, Jan, 2008
Chemoenzymatic synthesis, characterization, and application of glycopolymers carrying lactosamine repeats as entry inhibitors against influenza virus infection

Kazuya I.P.J. Hidari, Takeomi Murata, Kazuhiro Yoshida, Yoshiharu Takahashi, Yo-Hei Minamijima, Yoshinobu Miwa, Satoshi Adachi, Makoto Ogata, Taiichi Usui, Yasuo Suzuki …

Glycobiology, 18(10) 779-788, 2008
人工ムチンによる腸内有害菌の感染生育阻害剤の開発

村田健臣

平成16～18年度科学研究費補助金(基盤研究C)研究成果報告書, 1-148, May, 2007
Chemoenzymatic synthesis of artificial glycopolypeptides containing multivalent sialyloligosaccharides with a g-polyglutamic acid backbone and their effect for inhibition of infection by influenza viruses

責任著者]Ogata, 共著者]M, Murata T, Murakami K, Suzuki T, Hidari KI, Suzuki Y, Uusi T

BIOORGANIC & MEDICINAL CHEMISTRY, 15 1383-1393, Jan, 2007
Enzymatic synthesis of oligosaccharides and neoglycoconjugates

Takeomi Murata, Taichi Usui

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 70(5) 1049-1059, May, 2006
Isolation and characterization of a (]E0946[)-primeverosidase-like enzyme from Penicillium multicolor

責任著者]Tsuruhami K, 共著者]Mori S, Amarume S, Saruwatari S, Murata T, Hiratake J, Sakata K, Usui T

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 69 166-178, Jan, 2006
Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition.

責任著者]Nagae M, 共著者]Nishi N, Murata T, Usui T, Nakamura T, Wakatsuki S, Kato R

JOURNAL OF BIOLOGICAL CHEMISTRY, 281 35884-35893, Jan, 2006
Haire LF., Stevens DJ., Russell RJ., Gambin ST., Skehel JJ., and Kawaoka Hemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptor.

責任著者]Yamada S, 共著者]Suzuki Y, Suzuki T.,Le MQ, Nidom CA, Sakai-Tgawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K …

NATURE, 444 378-382, Jan, 2006
Kinetic studies on endo-(]E0946[)-galactosidase by a novel colorimetric assay and synthesis of poly-N-acetyllactosamines using transglycosylation activity.

責任著者]Murata T, 共著者]Honda H, Hattori T, Usui T

J. Appl. Glycosci, 52 161-168, Feb, 2005
Design and facile synthesis of neoglycolipids as lactosylceramide and transformation into glycoliposome

責任著者]Harada Y, 共著者]Murata T, Totani K, Kajimoto T, Masum S-D, Tamba Y, Yamazaki M, Usui T

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66(4) 801-807, Jan, 2005
Enzymatic synthesis of poly-N- acetyllactosamines as potential substrates for endo-(]E0946[)-galactosidase-catalyzed hydrolytic and transglycosylation reactions

責任著者]Murata T, 共著者]Honda H, Hattori T, Usui T

Biochim. Biophys. Acta,, 1722 60-68, Jan, 2005
Purification and characterization of a chitinase from Amycolatopsis orientalis with N-acetyllactosamine-repeating unit releasing activity

責任著者]Murata T, 共著者]Amarume S, Hattori T, Tokuyama S, Tokuyasu K, Kawagishi H, Usui T

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 336 514-520, Jan 1, 2005

Books and Other Publications

戦略的創造研究事業(CREST)糖鎖の生物機能の解明と利用技術

村田健臣 (Role: Joint author)

科学技術振興機構, Jan, 2009
Experimental Glycoscience, Glycobiology

Murata T, Uusi T (Role: Joint author)

Jan, 2008
未来を拓く糖鎖科学

村田健臣, 碓氷泰市 (Role: Joint author)

金芳堂, Dec, 2005
糖鎖科学の新展開

碓氷泰市, 村田健臣 (Role: Joint author)

エヌティーエス出版, Aug, 2005
糖鎖科学の最先端技術

村田健臣, 碓氷泰市 (Role: Joint author)

シーエムシー出版, Jun, 2005
糖鎖分子の設計と生理機能

碓氷泰市, 村田健臣 (Role: Joint author)

学会出版センター, Jan, 2001
アポトーシス実験プロトコール

村田健臣, 丸田英晴 (Role: Joint author)

秀潤社, Jan, 1999

Presentations

ピロリ菌生育阻害を目的としたGlcNAc 含有糖鎖ポリペプチドの合成

佐藤彩子, 近藤修啓, 星野瞳, 碓氷泰市, 朴龍洙, 中山淳, 村田健臣

第83回日本生化学会, Dec, 2010
アミロイドβ凝集阻害剤の合成

鈴木孝正, 伊藤直人, 村田健臣

第83回日本生化学会, Dec, 2010
Immunosuppressive effect of mucin on splenic marginal zone B cells in tumor-bearing state

戸田宗豊, 山下継史, 渡邊昌彦, 石田有希子, 秋田薫, 井上瑞江, 村田健臣, 碓氷泰市, 中田博

第83回日本生化学会, Dec, 2010
硫酸化糖含有人工ムチンとP-セレクチンとの相互作用解析

岩倉健司, 岡修平, 戸田宗豊, 碓氷泰市, 村田健臣, 中田博

第83回日本生化学会, Dec, 2010
ピロリ菌生育阻害を目的としたGlcNAc含有糖鎖ポリペプチドの合成

佐藤彩子, 近藤修啓, 星野瞳, 碓氷泰市, 朴龍洙, 中山淳, 村田健臣

第8回若手の力フォーラム, Sep, 2010
硫酸化糖含有人工ムチンとP-セレクチンとの相互作用解析

岩倉健司, 岡修平, 戸田宗豊, 碓氷泰市, 村田健臣, 中田博

第8回若手の力フォーラム, Sep, 2010
Chemoenzymatic synthesis of artificial mucins carrying sialylated O-linked glycans with a polylactosamine extension and interactions with CD22/siglec-2.

Murata T, Hattori T, Honda H, Toda M, Park E. Y, Usui T, Nakada H

25th International Carbohydrate Symposium, Aug, 2010
ピロリ菌生育遅延活性を持つ1,4GlcNAc含有糖鎖ポリペプチドの合成

近藤修啓, 星野瞳, 中山淳, 村田健臣, 静岡大農, 信州大医

2008年度日本糖質学会大会, Mar, 2008
シグレックに親和性を有するシアロ糖鎖含有人工ムチンの合成と機能解析

勝田真文, 太田麻利子, 戸田宗豊, 碓氷泰市, 村田健臣, 中田博, 静岡大,農, CREST, 京産大工

2008年度日本生化学会大会, Mar, 2008
静岡大農・応生化、1信州大医ピロリ菌生育遅延活性を持つα1,4GlcNAc含有糖鎖ポリペプチドの合成とα4GnTの基質特異性の検証

近藤修啓, 星野瞳, 中嶋真, 碓氷泰市, 朴龍洙, 中山淳, 村田健臣

2008年度日本農芸化学会大会, Mar, 2008
ピロリ菌生育遅延活性を持つ1,4GlcNAc含有糖鎖ポリペプチドの合成

近藤修啓, 星野瞳, 中山淳, 村田健臣, 静岡大農, 信州大医

2008年度日本糖質学会大会, Mar, 2008
硫酸化糖含有人工ムチンとマクロファージスカベンジャーレセプターとの相互作用解析

村田健臣, 戸田宗豊, 碓氷泰市, 中田博, 静岡大学農, 応生化, 科学技術振興機構, 京産大工, 生物工

2008年度日本糖質学会大会, Mar, 2008
ピロリ菌生育遅延活性をもつα1,4GlcNAc含有糖鎖ポリペプチドの合成

近藤修啓, 星野瞳, 村田健臣, 中山淳, 朴龍洙, 碓氷泰市, 静岡大農, 信州大医

2008年度日本生学会大会, Mar, 2008
シグレックに親和性を有するシアロ糖鎖含有人工ムチンの合成と機能解析

勝田真文, 太田麻利子, 戸田宗豊, 碓氷泰市, 村田健臣, 中田博, 静岡大,農, CREST, 京産大工

2008年度日本生化学会大会, Mar, 2008
硫酸化糖含有人工ムチンとマクロファージスカベンジャーレセプターとの相互作用解析

村田健臣, 戸田宗豊, 碓氷泰市, 中田博, 静岡大学農, 応生化, 科学技術振興機構, 京産大工, 生物工

2008年度日本糖質学会大会, Mar, 2008
シアリルオリゴ糖鎖含有ポリペプチドの合成とインフルエンザウイルス感染阻止活性

尾形慎, 酒井有子, 村田健臣, 碓氷泰市, 島田静美, 村上宏起, 左一八, 鈴木隆, 鈴木康夫, 野口利忠

第26回日本糖質学会年会(仙台), Aug, 2006
糖転移酵素の高感度活性測定基質の開発

高橋香元, 尾形慎, 村田健臣, 碓氷泰市

日本農芸化学会2006年度大会(京都), Mar, 2006
多価性シアリルオリゴ糖含有人工ムチンとSiglec-2との相互作用解析

藤田健太郎, 本多洋規, 高橋美生, 戸田宗豊, 中田博, 村田健臣, 朴龍洙, 碓氷泰市

日本農芸化学会2006年度大会(京都), Mar, 2006
シアリルオリゴ糖鎖含有ポリペプチドの合成とインフルエンザウイルス感染阻止活性

尾形慎, 酒井有子, 村田健臣, 碓氷泰市, 村上宏起, 鈴木隆, 鈴木康夫

日本農芸化学会2006年度大会(京都), Mar, 2006
Synthesis of 6'-Sulfodisaccharides by Aspergillus oryzae (]E0946[)-N-acetylhexosaminidase-catalyzed transglycosylation reaction.

Ogata,M, Zeng,X, Murata,T, Usui,T, Uzawa,H

GLYCO XVIII International Symposium on Glycoconjugates 2005, Sep, 2005

Teaching Experience

Professional Memberships

Research Projects

人工ムチンによる腸内有害菌の感染生育阻向剤の開発

基盤研究(C), 基盤研究(C), Apr, 2006
人工ムチンによる腸内有害菌の感染生育阻向剤の開発

基盤研究(C), 基盤研究(C), Apr, 2005
人工ムチンによる腸内有害菌の感染・生育阻害剤の開発

基盤研究(C), 基盤研究(C), Apr, 2004
胃ガンに特異的な新規糖鎖抗原の酵素合成と生体防御材料への展開

若手研究(B), 若手研究(B), Apr, 2003
胃ガンに特異的な新規糖鎖抗原の酵素合成と生体防御材料への展開

若手研究(B), 若手研究(B), Apr, 2002
オリゴ糖鎖ライブラリーによる細胞表層のグライコファームデザイン

奨励研究(A), 奨励研究(A), Apr, 2001
オリゴ糖鎖ライブラリーによる細胞表層のグライコフォームデザイン

奨励研究(A), 奨励研究(A), Apr, 2000