2006年4月
Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- 巻
- 342
- 号
- 2
- 開始ページ
- 568
- 終了ページ
- 572
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbrc.2006.02.009
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
WD40 repeat proteins have a wide range of diverse biological functions including signal transduction, cell cycle regulation, RNA splicing, and transcription. Here we report the identification and characterization of a novel human WD40 repeat protein, Monad. Monad is unique, since it contains only two WD40 repeats. Monad is widely expressed in human tissues with the highest expression in testis. Overexpression of Monad in HEK293 cells potentiated apoptosis and caspase-3 activation induced by tumor necrosis factor-alpha and cycloheximide. These results raise the possibility that Monad may function as a novel modulator of apoptosis pathway. (c) 2006 Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bbrc.2006.02.009
- ISSN : 0006-291X
- eISSN : 1090-2104
- PubMed ID : 16487927
- Web of Science ID : WOS:000236014500027