2006年7月
Progesterone receptor antagonist is effective in relieving neuropathic pain
EUROPEAN JOURNAL OF PHARMACOLOGY
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- 巻
- 541
- 号
- 1-2
- 開始ページ
- 44
- 終了ページ
- 48
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.ejphar.2006.05.010
- 出版者・発行元
- ELSEVIER SCIENCE BV
Injury to the spinal nerves of mice induces allodynia and hyperalgesia. Intrathecal injection of the progesterone/estrogen receptor antagonist ICI 182,780 produced antinociceptive effects. Co-administration of estrogen did not reduce but tended to enhance the antinociceptive effect of ICI 182,780. On the other hand, co-administration of progesterone dose-dependently reduced the antimociceptive effect of ICI 182,780, indicating that the antinociceptive effect is through antiprogesterone receptor activity of ICI 182,780. These results suggest that spinal progesterone receptors play an important role in neuropathic pain, and that controlling the activity of progesterone receptors may be of great importance in the treatment of neuropathic pain. (c) 2006 Elsevier B.V All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.ejphar.2006.05.010
- ISSN : 0014-2999
- PubMed ID : 16759651
- Web of Science ID : WOS:000238803700007