Tomoko Ohkusa

Profile Information

Affiliation: Lecturer, Faculty of Health Sciences Department of Nursing, Ube Frontier University

Degree: 医学博士(京都大学)

J-GLOBAL ID: 200901076140939638
researchmap Member ID: 1000222439

Research Interests

Cardiology

Research Areas

Research History

Apr, 2018 - Present

Faculty of Health Sciences, Department of Nursing, Ube Frontier University
Apr, 2016 - Mar, 2018

Faculty of Health Sciences, Ube Frontier University
Apr, 2016 - Mar, 2017

Kyushu University
Apr, 2015 - Mar, 2016

Kyushu University
Jan, 2014 - Mar, 2015

Kyushu University
Jan, 2009 - Dec, 2013

of Medicine, Graduate School, Yamaguchi University
2010

- Lecturer, , ,Graduate School of Medicine(Medicine),YAMAGUCHI UNIVERSITY
Apr, 2001 - Dec, 2008

School of Medicine, Yamaguchi University
Jun, 1997 - Mar, 2001

School of Medicine, Yamaguchi University
Apr, 1991 - May, 1997

Internal Medicine 2, Hospital, Yamaguchi University
May, 1988 - Dec, 1990

Harvard University
Apr, 1985 - Mar, 1987

医員, 循環器内科, 国立姫路病院
Apr, 1984 - Mar, 1985

研修医, 内科, 国立姫路病院
Jun, 1983 - Mar, 1984

研修医, 内科, 京都大学病院
Research Associate

Education

Apr, 1987 - Mar, 1991

医学研究科, 京都大学大学院
- 1991

Graduate School, Division of Medicine, Kyoto University
- 1983

Faculty of Medicine, Shimane Medical University
Shimane Medical University

Committee Memberships

Apr, 2019 - Present

評議員, 日本医学看護学教育学会
2019 - Present

生活習慣病対策委員会, 日本心臓病学会
2012 - Present

評議員, 日本心臓病学会
2012 - Present

社員（評議員）, 日本循環器学会
2000 - Present

日本心不全学会の評議委員, 日本心不全学会の評議委員
2001 - Dec, 2013

評議委員, 日本内科学会中国支部
2001 - Dec, 2013

評議委員, 日本循環器学会中国四国地方会

Awards

2000

山口大学医学会小西賞
1996

日本女医会研究助成

Papers

「A大学看護学科生における喫煙に対する意識および知識に関する学年別性差」

光貞美香, 澤田孝子, 柿並洋子, 江口恵里, 大塚和美, 名尾朋子, 大草知子

日本医学看護学教育学会誌, 28(1) 45-52, 2019 Peer-reviewed
「パルス性磁気照射の関節痛に対する効果の検討（第二報）－高齢者における検討－」

光貞美香, 川﨑幹子, 名尾朋子, 大草知子

日本医学看護学教育学会誌, 27(3) 12-18, 2019 Peer-reviewed
Peripartum Management of Pregnant Women with Congenital Heart Disease,

Yamasaki K, Sawatari H, Konagai N, Kamiya C, Yoshimatsu J, Muneuchi J, Watanabe M, Fukuda T, Mizuno A, Sakamoto I …

2019 Peer-reviewed
パルス性磁気照射の関節痛に対する効果の検討

大草知子, 澤田孝子, 川﨑幹子, 光貞美香, 名尾朋子

日本医学看護学教育学会誌, 27(1) 1-6, 2018 Peer-reviewed
Three nights leg thermal therapy could improve sleep quality in patients with chronic heart failure

Sawatari H, Nishizaka MK, Miyazono M, Ando S, Inoue S, Takemoto M, Sakamoto T, Goto D, Furumoto T, Kinugawa S …

Heart and Vessels, 33(2) 155-162, 2018 Peer-reviewed
A nationwide, cross-sectional survey on unusual sleep postures and sleep-disordered breathing-related symptoms in people with Down syndrome

H. Kuroda, H. Sawatari, S. Ando, T. Ohkusa, A. Rahmawati, J. Ono, M. Nishizaka, N. Hashiguchi, F. Matsuoka, A. Chishaki

JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 61(7) 656-667, Jul, 2017 Peer-reviewed
Effect of water bath temperature on physiological parameters and subjective sensation in older people,

Ono J, Hashiguchi N, Ohkusa T, Miyazono M, Son SY, Magota C, Sawatari H, Tochihara Y, Chishaki A

Geriatrics & Gerontology International, Apr, 2017 Peer-reviewed
Radial forces of stents used in thoracic endovascular aortic repair and bare self-expanding nitinol stents measured ex vivo - Rapid rescue for obstruction of the innominate artery using bare self-expanding nitinol stents

Takuya Matsumoto, Kentaro Inoue, Shinichi Tanaka, Yukihiko Aoyagi, Yutaka Matsubara, Daisuke Matsuda, Keiji Yoshiya, Ryosuke Yoshiga, Tomoko Ohkusa, Yoshihiko Maehara

VASCULAR, 25(1) 36-41, Feb, 2017 Peer-reviewed
Radial forces of stents used in thoracic endovascular aortic repair and bare self-expanding nitinol stents measured ex vivo - Rapid rescue for obstruction of the innominate artery using bare self-expanding nitinol stents

Takuya Matsumoto, Kentaro Inoue, Shinichi Tanaka, Yukihiko Aoyagi, Yutaka Matsubara, Daisuke Matsuda, Keiji Yoshiya, Ryosuke Yoshiga, Tomoko Ohkusa, Yoshihiko Maehara

VASCULAR, 25(1) 36-41, Feb, 2017 Peer-reviewed
Effects of chemotherapy on the health-related quality of life of Japanese lower rectal cancer patients after sphincter-saving surgery

Yumiko Kinoshita, Tomoko Ohkusa, Rieko Izukura, Akiko Chishaki, Ryuichi Mibu

JOURNAL OF PSYCHOSOCIAL ONCOLOGY, 35(4) 468-482, 2017 Peer-reviewed
Thermal inactivation of spores of Bacillus atrophaeus, Bacillus anthracis, Bacillus cereus, and Clostridium difficile,

Oie S, Ohkusa T, Kamiya A, Okutani A

Journal of Hospital Administration, 6(5) 9-11, 2017 Peer-reviewed
Efficacy of hot water against spores of Bacillus atrophaeus, Bacillus anthracis, Bacillus cereus, and Clostridium difficile,

Oie S, Ohkusa T, Kamiya A, Okutani A

Bacillus cereus, and Clostridium difficile, 2017 Peer-reviewed
Seasonal ambient changes influence inpatient falls

Magota C, Sawatari H, Ando S, Nishizawa M, Tanaka K, Horikoshi K, Hoashi I, Hashiguchi N, Ohkusa T, Chishaki A

Age and Aging,, 1-5, 2017 Peer-reviewed
Cardiac and respiratory effects of deep regional hyperthermia using an 8MHz radiofrequency-capacitive device on patients with cancer

Rieko Izukura, Hajime Imada, Nobuko Hashiguchi, Hiroyuki Sawatari, Takayuki Ohguri, Mami Miyazono, Shin Ohta, Chiduko Takakura, Keiko Yamasaki, Chie Magota …

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 33(4) 428-434, 2017 Peer-reviewed
BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality

Ayae Ikawa-Yoshida, Takuya Matsumoto, Shinji Okano, Yukihiko Aoyagi, Yutaka Matsubara, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Tomoko Ohkusa, Masatoshi Nomura, Mitsuho Onimaru …

Scientific Reports, 26, Aug, 2016 Peer-reviewed
Left Ventricular Ejection Fraction Predicts Severity of Posttraumatic Stress Disorder in Patients With Implantable Cardioverter-Defibrillators

Hiroyuki Sawatari, Tomoko Ohkusa, Anita Rahamawati, Katsuhiko Ishikawa, Miyuki Tsuchihashi-Makaya, Yuko Ohtsuka, Mori Nakai, Mami Miyazono, Nobuko Hashiguchi, Hiroaki Chishaki …

CLINICAL CARDIOLOGY, 39(5) 263-268, May, 2016 Peer-reviewed
Cumulative Hypoxemia During Sleep Predicts Vascular Endothelial Dysfunction in Patients With Sleep-Disordered Breathing

Hiroyuki Sawatari, Akiko Chishaki, Mari Nishizaka, Tomotake Tokunou, Sonomi Adachi, Chikara Yoshimura, Tomoko Ohkusa, Shin-ichi Ando

AMERICAN JOURNAL OF HYPERTENSION, 29(4) 458-463, Apr, 2016 Peer-reviewed
Obstructive sleep apnea-related symptoms in Japanese people with Down syndrome

Junji Ono, Akiko Chishaki, Tomoko Ohkusa, Hiroyuki Sawatari, Mari Nishizaka, Shin-ichi Ando

NURSING & HEALTH SCIENCES, 17(4) 420-425, Dec, 2015 Peer-reviewed
A longitudinal study of gender differences in quality of life among Japanese patients with lower rectal cancer treated with sphincter-saving surgery: a 1-year follow-up

Yumiko Kinoshita, Akiko Chishaki, Rieko Kawamoto, Tatsuya Manabe, Takashi Ueki, Keiji Hirata, Mami Miyazono, Maki Kanaoka, Akiko Tomioka, Masahiro Nakano …

WORLD JOURNAL OF SURGICAL ONCOLOGY, 13 91, Mar, 2015 Peer-reviewed
A Nationwide Cross-sectional Study on Congenital Heart Diseases and Symptoms of Sleep-disordered Breathing among Japanese Down's Syndrome People

Hiroyuki Sawatari, Akiko Chishaki, Mari Nishizaka, Fumio Matsuoka, Chikara Yoshimura, Hiromi Kuroda, Anita Rahmawati, Nobuko Hashiguchi, Mami Miyazono, Junji Ono …

INTERNAL MEDICINE, 54(9) 1003-1008, 2015 Peer-reviewed

Misc.

Altered expression of connexin43 contributes to the arrhythmogenic substrate during the development of heart failure in cardiomyopathic hamster

Takashi Sato, Tomoko Ohkusa, Haruo Honjo, Shinsuke Suzuki, Masa-aki Yoshida, Yuko S. Ishiguro, Harumichi Nakagawa, Masatoshi Yamazaki, Masafumi Yano, Itsuo Kodama …

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 294(3) H1164-H1173, Mar, 2008
Aldosterone modulates I-f current through gene expression in cultured neonatal rat ventricular myocytes

Takao Muto, Norihiro Ueda, Tobias Opthof, Tomoko Ohkusa, Kohzo Nagata, Shinsuke Suzuki, Yukiomi Tsuji, Mitsuru Horiba, Jong-Kook Lee, Haruo Honjo …

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 293(5) H2710-H2718, Nov, 2007
Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure

Mamoru Mochizuki, Masafumi Yano, Tetsuro Oda, Hiroki Tateishi, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Tomoko Ohkusa, Noriaki Ikemoto, Masunori Matsuzaki

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 49(16) 1722-1732, Apr, 2007
Beneficial effects of a dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters

Shinsuke Suzuki, Tomoko Ohkusa, Satoshi Takebayashi, Takashi Sato, Masa-aki Yoshida, Masafumi Yano, Katsushige Ono, Masunori Matsuzaki

Circulation Journal, 71(12) 1970-1976, 2007
Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure

M Yano, S Okuda, T Oda, T Tokuhisa, H Tateishi, M Mochizuki, T Noma, M Doi, S Kobayashi, T Yamamoto …

CIRCULATION, 112(23) 3633-3643, Dec, 2005
Sorcin interacts with sarcoplasmic reticulum Ca2+-ATPase and modulates excitation-contraction coupling in the heart

T Matsumoto, Y Hisamatsu, T Ohkusa, N Inoue, T Sato, S Suzuki, Y Ikeda, M Matsuzaki

BASIC RESEARCH IN CARDIOLOGY, 100(3) 250-262, May, 2005
心不全での不整脈基質としてのCa2+制御機構の異常とギャップ結合リモデリング

大草知子

心臓, 37(10) 871-879, 2005
Rapid Electrical Stimulation of Contraction Modulates Gap-Junction Protein in Neonatal Rat Cultured Cardiomyocytes Involvement of Mitogen-Activated Protein Kinases and Effects of Angiotensin II-Receptor Antagonist

INOUE Noriko, OHKUSA Tomoko, NAO Tomoko, LEE Jong-Kook, MATSUMOTO Tomo, HISAMATSU Yuji, SATOH Takashi, YANO Masafumi, YASUI Kenji, KODAMA Itsuo …

Yamaguchi Medical Journal, 54(4) 109-115, 2005
Defective Regulation of Interdomain Interactions Within the Ryanodine Receptor Plays a Key Role in the Pathogenesis of Heart Failure

Tetsuro Oda, Masafumi Yano, Takeshi Yamamoto, Takahiro Tokuhisa, Shinichi Okuda, Masahiro Doi, Tomoko Ohkusa, Yasuhiro Ikeda, Shigeki Kobayashi, Noriaki Ikemoto …

Circulation, 111(25) 3400-3410, 2005
Down-regulation of sarcolipin mRNA expression in chronic atrial fibrillation

N Uemura, T Ohkusa, K Hamano, M Nakagome, H Hori, M Shimizu, M Matsuzaki, S Mochizuki, S Minamisawa, Y Ishikawa

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 34(11) 723-730, Nov, 2004
ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

Y Mizukami, A Iwamatsu, T Aki, M Kimura, K Nakamura, T Nao, T Okusa, M Matsuzaki, K Yoshida, S Kobayashi

JOURNAL OF BIOLOGICAL CHEMISTRY, 279(48) 50120-50131, Nov, 2004
Valsartan restores sarcoplasmic reticulum function with no appreciable effect on resting cardiac function in pacing-induced heart failure

S Okuda, M Yano, M Doi, T Oda, T Tokuhisa, M Kohno, S Kobayashi, T Yamamoto, T Ohkusa, M Matsuzaki

CIRCULATION, 109(7) 911-919, Feb, 2004
Valsartan restores sarcoplasmic reticulum function with no appreciable effect on resting cardiac function in pacing-induced heart failure

S Okuda, M Yano, M Doi, T Oda, T Tokuhisa, M Kohno, S Kobayashi, T Yamamoto, T Ohkusa, M Matsuzaki

CIRCULATION, 109(7) 911-919, Feb, 2004
Rapid electrical stimulation of wntraction modulates gap-juntion protein in Neonatal rat cultured cardiomyocytes

JACC, 44, 914-922, 2004
Uemura N, Ohkusa T, hamano K, Nakagome M, Hori H, Shimizu M, Matsuzaki M, Mochizuki S, Manamisawa S, Ishikawa Y. Down-regulation od sarcolipin mRNA expression in chronic atrial fibrillation

Eur J Clin Invest, 2004
Mizukami Y, Iwamatu A, Kimura M, Nakamura K, Nao T, Ohkusa T, Matsuzaki M, Yoshida K, Kabayashi S. ERK1/2 regulates intracellular ATP levels through a-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

JBC, 2004
Rapid electrical stimulation of wntraction modulates gap-juntion protein in Neonatal rat cultured cardiomyocytes

JACC, 44, 914-922, 2004
Uemura N, Ohkusa T, hamano K, Nakagome M, Hori H, Shimizu M, Matsuzaki M, Mochizuki S, Manamisawa S, Ishikawa Y. Down-regulation od sarcolipin mRNA expression in chronic atrial fibrillation

Eur J Clin Invest, 2004
Mizukami Y, Iwamatu A, Kimura M, Nakamura K, Nao T, Ohkusa T, Matsuzaki M, Yoshida K, Kabayashi S. ERK1/2 regulates intracellular ATP levels through a-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

JBC, 2004
Comparison of expression of connexin in right atrial myocardium in patients with chronic atrial fibrillation versus those in sinus rhythm

T Nao, T Ohkusa, Y Hisamatsu, N Inoue, T Matsumoto, J Yamada, A Shimizu, Y Yoshiga, T Yamagata, S Kobayashi …

AMERICAN JOURNAL OF CARDIOLOGY, 91(6) 678-683, Mar, 2003

Books and Other Publications

「心不全×不整脈」

大草知子 (Role: Joint editor, 心不全における細胞内カルシウムハンドリングから見た不整脈”)

メディカ出版, 2016
徹底解説！心電図

大草知子 (Role: Joint editor, 心房負荷)

医学出版, Oct, 2015
不整脈学

大草知子 (Role: Joint author, Ca2+制御機構の異常)

南江堂, Sep, 2015
慢性心不全ガイドライン

日本臨床社, 2008
循環器疾患最新の治療 2008-2009

南江堂, 2008
心不全を予防する発症させない再発させないための診療ストラテジー

中山書店, 2006
エキスパートをめざす循環器診療心不全・ショック

南江堂, 2006
新目でみる循環器病シリーズ9 心不全－診断・治療・管理－

者湿酌叱勺射酌鹿鴫シメ, 2006
Molecular Mechanisms of Heart Disease 2005

Research Signpost, 2005
最新医学別冊新しい診断と治療のABC 33 慢性心不全

最新医学社, 2005
新・心臓病診療プラクティス 6.心不全に挑む・患者を救う

文光堂, 2005
酸化ストレスナビゲーター

メディカルレビュー社, 2005
疾患別最新処方

メジカルビュー社, 2005
シミュレイション内科心不全を探る

永井書店, 2004
心臓病の外来診療

日本医師会, 2004
EBM内科処方指針

中外医学社, 2004
心不全診療ガイダンス

メジカルビュー社, 2004
ダイナミックメディシン

西村書店, 2003
循環器New Trendsシリーズ４

メジカルビュー社, 2003
EBM内科処方ノート

中外医学社, 2003

Presentations

132

簡易睡眠検査を用いたダウン症児と健常児における睡眠呼吸障害の検討、

森山宣子, 大草知子, 名尾朋子, 澤渡浩之, 橋口暢子, 宮園真美, Anita Rahmawati, 姜旻廷, 藤田香奈恵, 西坂麻里, 安藤眞一, 樗木晶子

第43回日本睡眠学会定期学術集会, Jul, 2018
小児睡眠呼吸障害のスクリーニングについて－パルスオキシメータ－検査を用いた検討－、

名尾朋子, Anita Rahmawati, 森山宣子, 西坂麻里, 澤渡浩之, 樗木晶子

第43回日本睡眠学会定期学術集会, Jul, 2018
看護学生の自我状態と自己愛傾向との関連についての検討

柿並洋子, 名尾朋子, 大草知子

第38回日本看護科学学会学術集会、, 2018
先天性心疾患合併の多いダウン症児における睡眠呼吸障害の検討－非ダウン症児との比較―、

森山宣子, 樗木晶子, 澤渡浩之, 西坂麻里, Anita Rahmawati, 宮園真美, 橋口暢子, 大草知子, 名尾朋子, 安藤眞一

第54回日本循環器病予防学会学術集会, 2018
「手指衛生の保持における温水洗浄便座の有効性」

青鹿宏美, 尾家重治, 有田恵美子, 原田博子, 大草知子

第11回日本性差医学・医療学会学術集会, Jan, 2018
看護大学生の喫煙健康被害の認識と喫煙関連知識に関する性差の検討

光貞美香, 澤田孝子, 大塚和美, 名尾朋子, 大草知子

第11回日本性差医学・医療学会学術集会, Jan, 2018
「定期的な磁場照射が関節痛に及ぼす安全性と効果の検討」

川崎幹子, 光貞美香, 澤田孝子, 大草知子, 名尾朋子

第37回日本看護科学学会, Dec, 2017
「介護保険施設における印字パンツ使用による効果の検討」

光貞美香, 川崎幹子, 大草知子

第37回日本看護科学学会, Dec, 2017
「Pediatric sleep-disordered breathing in Japan」

OHKUSA Tomoko

The 11th Sleep Respiration Forum in Hawaii combined with Hawaii Sleep Society,, Dec, 2017 Invited
「室内照度が高齢者の食欲に与える影響の検討」

光貞美香, 名尾朋子, 大草知子

第23回日本摂食嚥下リハビリテーション学会学術大会, Sep, 2017
不整脈発生気質としての細胞間接着構成タンパク異状－モデル動物での検討

第93回日本循環器学会中国地方会, 2008
「Mutation-Linked&Defective Inter-Domain Interaction within the Cardiac Ryanodine Receptor as a Critical Cause of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

Circulation, 2008
「Decreased Affinity of Calmodulin Binding to RyR2 May Cause Leaky Channel in CPVT-Associated Mutation: Insight from RyR2 R2474S/+ Knock-In Mouse Model 」<br>

Circulation<br>, 2008
Abnormally Tight Domain-Domain Interaction at Mutation Site Could be a Primary Cause of Catecholaminergic Polymorphic Ventricular Tachycardia: Insight from RyR2 S2246L/+ Knock-In Mouse Model

Circulation, 2008
Defective Inter-domain Interaction May Cause Spontaneous Ca2+ Release Via Reduced Affinity of Calmodulin Binding to RyR2 in Failing Hearts

Circulation<br>, 2008
レニン・アンジオテンシン・アルドステロン系とギャップ結合リモデリングについて

第14回Circulation Club レニン・アンジオテンシン・アルドステロン, 2008
肥大型心筋症の経過中に拘束性の血行動態を呈した一例

Circ J, 2008
TCC研究の進展と今後の期待

第5回TCCフォーラム<br>, 2008
慢性心不全患者における酸化ストレスマーカー：尿8-hydroxy-2-deoxyguanosine(8-OHdG)の有用性について

日本内科学会雑誌, 2008
Abnormally Tight Domain-Domain Interaction at Mutation Site could be a Primary Cause of Catecholaminergic Polymorphic Ventricular Tachycardia

Circ J, 2008

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