2016年
A dramatic enhancing effect of InBr3 towards the oxidative Sonogashira cross-coupling reaction of 2-ethynylanilines
ORGANIC & BIOMOLECULAR CHEMISTRY
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- 巻
- 14
- 号
- 6
- 開始ページ
- 2127
- 終了ページ
- 2133
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c5ob02558c
- 出版者・発行元
- ROYAL SOC CHEMISTRY
The addition of InBr3 to the oxidative Sonogashira cross-coupling reaction of 2-ethynylaniline with (E)-trimethyl(3,3,3-trifluoroprop-1-enyl)silane led to a dramatic increase in the reactivity to afford the corresponding 1,3-enynes bearing a trifluoromethyl group on their terminal sp(2) carbon. The subsequent cyclization of these 1,3-enynes under palladium catalysis provides access to the corresponding indoles bearing a 3,3,3-trifluoroprop-1-enyl group at their 2-position.
- リンク情報
- ID情報
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- DOI : 10.1039/c5ob02558c
- ISSN : 1477-0520
- eISSN : 1477-0539
- Web of Science ID : WOS:000369601600024