Recently, application of hydrogen energy has been expanded. For more safe and efficient use of hydrogen, study of bubble nucleation in liquid hydrogen is necessary. Various studies already have reported the quantum nature effects on thermodynamic and transport properties. Therefore, it is expected that quantum nature also influences bubble nucleation. We reproduced quantum liquid hydrogen using path integral centroid Molecular Dynamics (MD) method and also simulated virtual classical liquid hydrogen with classical MD. First, we compared the energy barrier for bubble nucleation and the critical bubble size using Classical Nucleation Theory. Next, we investigated quantity of void in both fluids with local density function. In consequence, it is suggested that quantum nature affects bubble nucleation, and quantum hydrogen is difficult to create a bubble nucleus than classical hydrogen.