2009年
Peroxisome proliferator-activated receptor γ negativety regulated allergic rhinitis in mice
Allergology International
- ,
- ,
- ,
- 巻
- 58
- 号
- 2
- 開始ページ
- 247
- 終了ページ
- 253
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2332/allergolint.08-OA-0047
- 出版者・発行元
- Japanese Society of Allergology
Background: Peroxisome proliferator-activated receptor γ (PPAR-γ) has been shown to play an important role in the control of inflammatory responses acting on macrophages, mast cells, T cells, and eosinophils. The present study was aimed at investigating the effects of PPAR-γ agonist on nasal symptoms and eosinophil accumulations in nasal mucosa by using a murine allergic rhinitis model. Furthermore, we examined the expression of PPAR-γ in the nasal mucosa in mice. Methods: BALBac mice were sensitized and challenged intranasally with ovalbumin. Ciglitazone, a PPAR-γ agonist, was administered orally 6 hours before each nasal challenge. Results: Administration of PPAR-γ agonist significantly decreased the number of nasal rubs, nasal histamine responsiveness, serum IgE, IL-5 production from the spleen, and eosinophilic infiltration in the nasal mucosa. Furthermore, PPAR-γ was expressed in eosinophils and epithelial cells in the nasal mucosa by immunohistochemistry. Conclusions: PPAR-γ was expressed in eosinophils and epithelial cells in the nasal mucosa. Also, the oral administration of ciglitazone is effective in upper airway allergic inflammation in mice. © 2009 Japanese Society of Allergology.
- リンク情報
- ID情報
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- DOI : 10.2332/allergolint.08-OA-0047
- ISSN : 1440-1592
- ISSN : 1323-8930
- PubMed ID : 19307774
- SCOPUS ID : 67651148388