2000年2月
Murine CD1d-restricted T cell recognition of cellular lipids
IMMUNITY
- 巻
- 12
- 号
- 2
- 開始ページ
- 211
- 終了ページ
- 221
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- CELL PRESS
NKT cells are associated with immunological control of autoimmune disease and cancer and can recognize cell surface mCD1d without addition of exogenous antigens. Cellular antigens presented by mCD1d have not been identified, although NKT cells can recognize a synthetic glycolipid, alpha-GalCer. Here we show that after addition of a lipid extract from a tumor cell line, plate-bound mCD1d molecules stimulated an NKT cell hybridoma. This hybridoma also responded strongly to three purified phospholipids, but failed to recognize alpha-GalCer. Seven of sixteen other mCD1d restricted hybridomas also showed a response to certain purified phospholipids. These findings suggest NKT cells can recognize cellular antigens distinct from alpha-GalCer and identify phospholipids as potential self-antigens presented by mCD1d.
- リンク情報
- ID情報
-
- ISSN : 1074-7613
- PubMed ID : 10714687
- Web of Science ID : WOS:000085621400011