2016年11月
B cells and their role in the teleost gut
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
- ,
- ,
- ,
- 巻
- 64
- 号
- 開始ページ
- 150
- 終了ページ
- 166
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.dci.2016.03.013
- 出版者・発行元
- ELSEVIER SCI LTD
Mucosal surfaces are the main route of entry for pathogens in all living organisms: In the case of teleost fish, mucosal surfaces cover the vast majority of the animal. As these surfaces are in constant contact with the environment, fish are perpetually exposed to a vast number of pathogens. Despite the potential prevalence and variety of pathogens, mucosal surfaces are primarily populated by commensal nonpathogenic bacteria. Indeed, a fine balance between these two populations of microorganisms is crucial for animal survival. This equilibrium, controlled by the mucosal immune system, maintains homeostasis at mucosal tissues. Teleost fish possess a diffuse mucosa-associated immune system in the intestine, with B cells being one of the main responders. Immunoglobulins produced by these lymphocytes are a critical line of defense against pathogens and also prevent the entrance of commensal bacteria into the epithelium. In this review we will summarize recent literature regarding the role of B lymphocytes and immunoglobulins in gut immunity in teleost fish, with specific focus on immunoglobulin ishtypes and the microorganisms, pathogenic and non-pathogenic that interact with the immune system. (C) 2016 Published by Elsevier Ltd.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.dci.2016.03.013
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000380623800015&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-84962368284&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-0988-2770
- ID情報
-
- DOI : 10.1016/j.dci.2016.03.013
- ISSN : 0145-305X
- eISSN : 1879-0089
- ORCIDのPut Code : 23747366
- SCOPUS ID : 84962368284
- Web of Science ID : WOS:000380623800015