2014年11月
Broad Integration of Expression Maps and Co-Expression Networks Compassing Novel Gene Functions in the Brain
SCIENTIFIC REPORTS
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- 巻
- 4
- 号
- 開始ページ
- 6969
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/srep06969
- 出版者・発行元
- NATURE PUBLISHING GROUP
Using a recently invented technique for gene expression mapping in the whole-anatomy context, termed transcriptome tomography, we have generated a dataset of 36,000 maps of overall gene expression in the adult-mouse brain. Here, using an informatics approach, we identified a broad co-expression network that follows an inverse power law and is rich in functional interaction and gene-ontology terms. Our framework for the integrated analysis of expression maps and graphs of co-expression networks revealed that groups of combinatorially expressed genes, which regulate cell differentiation during development, were present in the adult brain and each of these groups was associated with a discrete cell types. These groups included non-coding genes of unknown function. We found that these genes specifically linked developmentally conserved groups in the network. A previously unrecognized robust expression pattern covering the whole brain was related to the molecular anatomy of key biological processes occurring in particular areas.
- リンク情報
- ID情報
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- DOI : 10.1038/srep06969
- ISSN : 2045-2322
- PubMed ID : 25382412
- Web of Science ID : WOS:000344759000004