Apr, 2018 - Mar, 2021
Genetic analysis in the life prolonging effect of low dose radiation, and applications as biomarkers
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
- Grant number
- 18K07774
- Japan Grant Number (JGN)
- JP18K07774
- Grant amount
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- (Total)
- 4,420,000 Japanese Yen
- (Direct funding)
- 3,400,000 Japanese Yen
- (Indirect funding)
- 1,020,000 Japanese Yen
In the p53 gene normal 8-week-old mice, lifespan in the 2cGy+3Gy irradiated group extended than 3Gy alone irradiated group. There was no life-prolonging effect in p53 gene heterozygous mice (half the amount of p53) and 40-week-old mice. Expression of the p53 gene decreased at 40 weeks compared to 8 weeks of age, and there was no difference in the development of apoptosis between the 2cGy + 3Gy group and the 3Gy group. In the analysis of microRNAs that play an important role in biological phenomena, the microRNAs expressed in each irradiation group of 0Gy, 2cGy, 2cGy + 3Gy, and 3Gy were different. It was suggested that microRNAs could be biomarkers.
- Link information
- ID information
-
- Grant number : 18K07774
- Japan Grant Number (JGN) : JP18K07774
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Scientific Reports, 11(1) 12357-12357, Jun, 2021 Peer-reviewedLead authorCorresponding author