1989
Suppression of mast cell colony formation by a low molecular weight fraction of fetal calf bone marrow extract.
Leukemia research
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- Volume
- 13
- Number
- 12
- First page
- 1085
- Last page
- 9
- Language
- English
- Publishing type
- Research paper (scientific journal)
A semi-purified fraction extracted from fetal calf bone marrow was previously shown to contain a tetrapeptide N-Ac-Ser-Asp-Lys-Pro which inhibits in mice, hematopoietic stem cell entry into the cell cycle. This peptide however, did not exhibit any effect on either IL-3 nor GM-CSF dependent cell growth. We report herein that a semi-purified fraction also contains another activity which is antagonistic to IL-3. Addition of the fraction in vitro decreased IL-3 dependent mast cell colony formation. Growth of IL-3 dependent cell lines (DA-1 and FDC-P2) was also suppressed. No effect was observed in the same dose range on granulocyte-macrophage colony formation nor on IL-3 independent cell growth.
- Link information
- ID information
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- ISSN : 0145-2126
- Pubmed ID : 2615466