Satoshi Hirohata

Profile Information

Affiliation: Professor, Graduate School of Health Sciences, Okayama University

Degree: 博士（医学）(岡山大学)

J-GLOBAL ID: 200901011892711607
researchmap Member ID: 5000011752

External link: http://www.fhs.okayama-u.ac.jp/

Research Interests

Research Areas

Major Research History

2014

- 岡山大学保健学研究科教授

Education

- 1997

Okayama University
- 1992

Medical School, Okayama University
- 1992

Faculty of Medicine, Okayama University

Committee Memberships

Awards

Sep, 2018

Best poster presentation award, Bile acid metabolic disorder aggravates cardiac dysfunction in SHRSP5/Dmcr rat that induced non-alcoholic steatohepatitis, The 7th International Congress on Lipid & Atherosclerosis 2018

Shota Kumazaki, Shun Sasaki, Rina Tagashira, Mayu Nakamura, Nozomi Maruyama, Satoshi Hirohata, Shogo Watanabe
Sep, 2018

Best poster presentation award, Non-alcoholic steatohepatitis aggravates myocardial infarction induced by NO synthase inhibitor, The 18th International SHR Symposium (official satellite symposium of ISH2018)

Shota Kumazaki, Shun Sasaki, Rina Tagashira, Mayu Nakamura, Nozomi Maruyama, Satoshi Hirohata, Hisao Oka, Shogo Watanabe
2008

岡山大学若手トップリサーチャー研究奨励賞, 岡山大学
May, 2007

優秀演題賞, Ⅳ型コラーゲンNC1ドメインの腫瘍特異的発現は内皮細胞の管腔形成とマウスでの腫瘍発育を阻害する, 日本結合組織学会

Major Papers

194

Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism.

Ikumi Sato, Shusei Yamamoto, Mai Kakimoto, Moe Fujii, Koki Honma, Shota Kumazaki, Mami Matsui, Hinako Nakayama, Sora Kirihara, Shang Ran …

Pharmacological reports : PR, 74(4) 669-683, Aug, 2022 Peer-reviewed
A high-fat/high-cholesterol diet, but not high-cholesterol alone, increases free cholesterol and apoE-rich HDL serum levels in rats and upregulates hepatic ABCA1 expression.

Ryoko Shinohata, Misako Shibakura, Yujiro Arao, Shogo Watanabe, Satoshi Hirohata, Shinichi Usui

Biochimie, 197 49-58, Jun, 2022 Peer-reviewed
Potential of a Novel Chemical Compound Targeting Matrix Metalloprotease-13 for Early Osteoarthritis: An In Vitro Study.

Junko Inagaki, Airi Nakano, Omer Faruk Hatipoglu, Yuka Ooka, Yurina Tani, Akane Miki, Kentaro Ikemura, Gabriel Opoku, Ryosuke Ando, Shintaro Kodama …

International journal of molecular sciences, 23(5), Feb 28, 2022 Peer-reviewedCorresponding author
Osteopontin silencing attenuates bleomycin-induced murine pulmonary fibrosis by regulating epithelial–mesenchymal transition

Omer Faruk Hatipoglu, Eyyup Uctepe, Gabriel Opoku, Hidenori Wake, Kentaro Ikemura, Takashi Ohtsuki, Junko Inagaki, Mehmet Gunduz, Esra Gunduz, Shogo Watanabe …

Biomedicine & Pharmacotherapy, 139 111633-111633, Jul, 2021 Peer-reviewedLast authorCorresponding author
Low plasma apolipoprotein E-rich high-density lipoprotein levels in patients with metabolic syndrome

Ryoko Shinohata, Yuhei Shiga, Shin-ichiro Miura, Satoshi Hirohata, Misako Shibakura, Tomoe Ueno-Iio, Shogo Watanabe, Yujiro Arao, Shinichi Usui

CLINICA CHIMICA ACTA, 510 531-536, Nov, 2020 Peer-reviewed
Efficacy of an Adjunctive Electrophysiological Test–Guided Left Atrial Posterior Wall Isolation in Persistent Atrial Fibrillation Without a Left Atrial Low-Voltage Area

Hirosuke Yamaji, Shunichi Higashiya, Takashi Murakami, Kazuyoshi Hina, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi

Circulation: Arrhythmia and Electrophysiology, 13(8) e008191, Aug, 2020 Peer-reviewed
Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis.

Takashi Ohtsuki, Omer F Hatipoglu, Keiichi Asano, Junko Inagaki, Keiichiro Nishida, Satoshi Hirohata

International journal of molecular sciences, 21(9), Apr 29, 2020 Peer-reviewedLast authorCorresponding author
Deficiency of CD44 prevents thoracic aortic dissection in a murine model.

Omer F Hatipoglu, Toru Miyoshi, Tomoko Yonezawa, Megumi Kondo, Naofumi Amioka, Masashi Yoshida, Satoshi Akagi, Kazufumi Nakamura, Satoshi Hirohata, Hiroshi Ito

Scientific reports, 10(1) 6869-6869, Apr 22, 2020 Peer-reviewed
Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1.

Takashi Ohtsuki, Akira Shinaoka, Kanae Kumagishi-Shinaoka, Keiichi Asano, Omer Faruk Hatipoglu, Junko Inagaki, Ken Takahashi, Toshitaka Oohashi, Keiichiro Nishida, Keiji Naruse …

Experimental cell research, 383(2) 111556-111556, Oct 15, 2019 Peer-reviewedLast authorCorresponding author
Serum malondialdehyde-modified low-density lipoprotein levels on admission predict prognosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Naofumi Amioka, Toru Miyoshi, Hiroaki Otsuka, Daisuke Yamada, Atsushi Takaishi, Masayuki Ueeda, Satoshi Hirohata, Hiroshi Ito

JOURNAL OF CARDIOLOGY, 74(3-4) 258-266, Sep, 2019 Peer-reviewed
Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model

Shogo Watanabe, Shota Kumazaki, Shusei Yamamoto, Ikumi Sato, Kazuya Kitamori, Mari Mori, Yukio Yamori, Satoshi Hirohata

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 99(6) 282-294, Dec, 2018 Peer-reviewed
High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression.

Takashi Ohtsuki, Keiichi Asano, Junko Inagaki, Akira Shinaoka, Kanae Kumagishi-Shinaoka, Mehmet Z Cilek, Omer F Hatipoglu, Toshitaka Oohashi, Keiichiro Nishida, Issei Komatsubara …

Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 36(12) 3247-3255, Dec, 2018 Peer-reviewedLast authorCorresponding author
Differences in activated clotting time and initial heparin dosage during atrial fibrillation ablation for patients with edoxaban compared with warfarin

Hirosuke Yamaji, Takashi Murakami, Kazuyoshi Hina, Shunichi Higashiya, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi

Journal of Cardiovascular Electrophysiology, 29(6) 835-843, Jun 1, 2018 Peer-reviewed
Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth.

Keiichi Asano, Midori Edamatsu, Omer F Hatipoglu, Junko Inagaki, Mitsuaki Ono, Takashi Ohtsuki, Toshitaka Oohashi, Satoshi Hirohata

Acta medica Okayama, 72(3) 257-266, Jun, 2018 Peer-reviewedCorresponding author
A high-fat and high-cholesterol diet induces cardiac fibrosis, vascular endothelial, and left ventricular diastolic dysfunction in shrsp5/dmcr rats

Shogo Watanabe, Shota Kumazaki, Katsuhiro Kusunoki, Terumi Inoue, Yui Maeda, Shinichi Usui, Ryoko Shinohata, Takashi Ohtsuki, Satoshi Hirohata, Shozo Kusachi …

Journal of Atherosclerosis and Thrombosis, 25(5) 439-453, 2018 Peer-reviewed
Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis

Keiichi Asano, Courtney M. Nelson, Sumeda Nandadasa, Noriko Aramaki-Hattori, Daniel J. Lindner, Tyler Alban, Junko Inagaki, Takashi Ohtsuki, Toshitaka Oohashi, Suneel S. Apte …

SCIENTIFIC REPORTS, 7(1) 2101-2105, Dec, 2017 Peer-reviewed
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

Kazuhiro Yamamoto, Hiroshi Okano, Wakako Miyagawa, Robert Visse, Yasuyuki Shitomi, Salvatore Santamaria, Jayesh Dudhia, Linda Troeberg, Dudley K. Strickland, Satoshi Hirohata …

MATRIX BIOLOGY, 56 57-73, Dec, 2016 Peer-reviewed
Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice

Saran Kumar, Mo Chen, Yan Li, Fiona H. S. Wong, Chung Wee Thiam, Md Zakir Hossain, Kian Keong Poh, Satoshi Hirohata, Hiroko Ogawa, Veronique Angeli …

SCIENTIFIC REPORTS, 6 31130-31130, Aug, 2016 Peer-reviewed
Interleukin-1 induced nuclear factor-B binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells

Aynur Altuntas, Sevil Oskay Halacli, Ozlem Cakmak, Gonul Erden, Sumeyya Akyol, Veli Ugurcu, Satoshi Hirohata, Kadir Demircan

MOLECULAR MEDICINE REPORTS, 12(1) 595-600, Jul, 2015 Peer-reviewed
ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor.

Junko Inagaki, Katsuyuki Takahashi, Hiroko Ogawa, Keiichi Asano, Omer Faruk Hatipoglu, Mehmet Zeynel Cilek, Masanari Obika, Takashi Ohtsuki, Matthias Hofmann, Shozo Kusachi …

Experimental cell research, 323(2) 263-75, May 1, 2014 Peer-reviewedLast authorCorresponding author
ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury

Kadir Demircan, Vehap Topcu, Tomoyuki Takigawa, Sumeyya Akyol, Tomoko Yonezawa, Gulfer Ozturk, Veli Ugurcu, Rukiye Hasgul, M. Ramazan Yigitoglu, Omer Akyol …

BIOMED RESEARCH INTERNATIONAL, 2014(2014) 693746-693746, 2014 Last author
Augmentation of ADAMTS9 gene expression by IL-1 beta is reversed by NF kappa B and MAPK inhibitors, but not PI3 kinase inhibitors

Sema Uysal, Zahide Nur Unal, Serpil Erdogan, Sumeyya Akyol, M. Ramazan Yigitoglu, Satoshi Hirohata, Bunyamin Isik, Kadir Demircan

CELL BIOCHEMISTRY AND FUNCTION, 31(7) 539-544, Oct, 2013 Peer-reviewed
Vascular endothelial growth factor C-induced lymphangiogenesis decreases tumor interstitial fluid pressure and tumor.

Matthias Hofmann, Ralph Pflanzer, Nadja Nicole Zoller, August Bernd, Roland Kaufmann, Diamant Thaci, Jurgen Bereiter-Hahn, Satoshi Hirohata, Stefan Kippenberger

Translational oncology, 6(4) 398-404, Aug, 2013 Peer-reviewed
ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse

Kadir Demircan, Tomoko Yonezawa, Tomoyuki Takigawa, Vehap Topcu, Serpil Erdogan, Fatma Ucar, Ferah Armutcu, M. Ramazan Yigitoglu, Yoshifumi Ninomiya, Satoshi Hirohata

NEUROSCIENCE LETTERS, 544 25-30, Jun, 2013 Peer-reviewed
Eosinophil cationic protein enhances stabilization of beta-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells

Guoliang Jin, Akifumi Mizutani, Takayuki Fukuda, Takayuki Otani, Ting Yan, Marta Prieto Vila, Hiroshi Murakami, Takayuki Kudoh, Satoshi Hirohata, Tomonari Kasai …

MOLECULAR BIOLOGY REPORTS, 40(4) 3165-3171, Apr, 2013 Peer-reviewed
Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway

Guoliang Jin, Akifumi Mizutani, Takayuki Fukuda, Ling Chen, Keisuke Nakanishi, Ting Yan, Takayuki Kudoh, Satoshi Hirohata, Tomonari Kasai, Hiroshi Murakami …

GROWTH FACTORS, 30(5) 344-355, Oct, 2012 Peer-reviewed
Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis.

Masanari Obika, Hiroko Ogawa, Katsuyuki Takahashi, Jiayi Li, Omer Faruk Hatipoglu, Mehmet Zeynel Cilek, Toru Miyoshi, Junko Inagaki, Takashi Ohtsuki, Shozo Kusachi …

Cancer science, 103(10) 1889-97, Oct, 2012 Peer-reviewed
Four-year clinical outcomes of the OLIVUS-Ex (impact of Olmesartan on progression of coronary atherosclerosis: Evaluation by intravascular ultrasound) extension trial

Atsushi Hirohata, Keizo Yamamoto, Toru Miyoshi, Kunihiko Hatanaka, Satoshi Hirohata, Hitoshi Yamawaki, Issei Komatsubara, Eiki Hirose, Yuhei Kobayashi, Keisuke Ohkawa …

ATHEROSCLEROSIS, 220(1) 134-138, Jan, 2012 Peer-reviewed
Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men

Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Kazufumi Nakamura, Shinichi Usui, Ko Takeda, Mutsumi Iwamoto, Shozo Kusachi, Kengo Kusano, Hiroshi Ito

CARDIOVASCULAR DIABETOLOGY, 10 44-44, May, 2011 Peer-reviewed
Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells

T. Tetsunaga, K. Nishida, T. Furumatsu, K. Naruse, S. Hirohata, A. Yoshida, T. Saito, T. Ozaki

OSTEOARTHRITIS AND CARTILAGE, 19(2) 222-232, Feb, 2011 Peer-reviewed
AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo.

Mehmet Zeynel Cilek, Satoshi Hirohata, Omer Faruk Hatipoglu, Hiroko Ogawa, Toru Miyoshi, Junko Inagaki, Takashi Ohtsuki, Hiroshi Harada, Shigeshi Kamikawa, Shozo Kusachi …

Cell biology international, 35(1) 1-8, Jan, 2011 Peer-reviewed
Connective tissue growth factor induction in a pressure-overloaded heart ameliorated by the angiotensin II type 1 receptor blocker olmesartan

Mutsumi Iwamoto, Satoshi Hirohata, Hiroko Ogawa, Takashi Ohtsuki, Ryoko Shinohata, Toru Miyoshi, O. Faruk Hatipoglu, Shozo Kusachi, Kazuhide Yamamoto, Yoshifumi Ninomiya

HYPERTENSION RESEARCH, 33(12) 1305-1311, Dec, 2010 Peer-reviewed
Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis

Tomoko Kawabata, Keiichiro Nishida, Koji Takasugi, Hiroko Ogawa, Kenei Sada, Yasutaka Kadota, Junko Inagaki, Satoshi Hirohata, Yoshifumi Ninomiya, Hirofumi Makino

Arthritis Research and Therapy, 12(4) R133, Jul 7, 2010 Peer-reviewed
Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound

Toru Miyoshi, Go Onoue, Atsushi Hirohata, Satoshi Hirohata, Shinichi Usui, Kazuyoshi Hina, Hiroshi Kawamura, Masayuki Doi, Kengo Fukushima Kusano, Shozo Kusachi …

ATHEROSCLEROSIS, 211(1) 164-169, Jul, 2010 Peer-reviewed
Type IV Collagen Induces Expression of Thrombospondin-1 that is Mediated by Integrin alpha 1 beta 1 in Astrocytes

Tomoko Yonezawa, Shunji Hattori, Junko Inagaki, Masae Kurosaki, Tomoyuki Takigawa, Satoshi Hirohata, Toru Miyoshi, Yoshifumi Ninomiyai

GLIA, 58(7) 755-767, May, 2010 Peer-reviewed
Impact of Olmesartan on Progression of Coronary Atherosclerosis A Serial Volumetric Intravascular Ultrasound Analysis From the OLIVUS (Impact of OLmesarten on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound) Trial

Atsushi Hirohata, Keizo Yamamoto, Toru Miyoshi, Kunihiko Hatanaka, Satoshi Hirohata, Hitoshi Yamawaki, Issei Komatsubara, Masaaki Murakami, Eiki Hirose, Shinji Sato …

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 55(10) 976-982, Mar, 2010 Peer-reviewed
Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis

K. Ayada, K. Yokota, K. Hirai, K. Fujimoto, K. Kobayashi, H. Ogawa, K. Hatanaka, S. Hirohata, T. Yoshino, Y. Shoenfeld …

LUPUS, 18(13) 1154-1168, Nov, 2009 Peer-reviewed
ADAMTS1 Is a Unique Hypoxic Early Response Gene Expressed by Endothelial Cells

Omer F. Hatipoglu, Satoshi Hirohata, M. Zeynel Cilek, Hiroko Ogawa, Toru Miyoshi, Masanari Obika, Kadir Demircan, Ryoko Shinohata, Shozo Kusachi, Yoshifumi Ninomiya

JOURNAL OF BIOLOGICAL CHEMISTRY, 284(24) 16325-16333, Jun, 2009 Peer-reviewedCorresponding author
INCREASED mRNA EXPRESSION OF ADAMTS METALLOPROTEINASES IN METASTATIC FOCI OF HEAD AND NECK CANCER

Kadir Demircan, Esra Gunduz, Mehmet Gunduz, Levent Bekir Beder, Satoshi Hirohata, Hitoshi Nagatsuka, Beyhan Cengiz, Mehmet Zeynel Cilek, Noboru Yamanaka, Kenji Shimizu …

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 31(6) 793-801, Jun, 2009 Peer-reviewed
The 3'-untranslated region of ADAMTS1 regulates its mRNA stability.

Omer Faruk Hatipoglu, Satoshi Hirohata, Kursat Oguz Yaykasli, Mehmet Zeynel Cilek, Kadir Demircan, Ryoko Shinohata, Tomoko Yonezawa, Toshitaka Oohashi, Shozo Kusachi, Yoshifumi Ninomiya

Acta medica Okayama, 63(2) 79-85, Apr, 2009 Peer-reviewedCorresponding author
ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes.

Kursat Oguz Yaykasli, Toshitaka Oohashi, Satoshi Hirohata, Omer Faruk Hatipoglu, Kiichi Inagawa, Kadir Demircan, Yoshifumi Ninomiya

Molecular and cellular biochemistry, 323(1-2) 69-79, Mar, 2009 Peer-reviewed
Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen anti body-induced arthritis mouse model

Y. Nasu, K. Nishida, S. Miyazawa, T. Komiyama, Y. Kadota, N. Abe, A. Yoshida, S. Hirohata, A. Ohtsuka, T. Ozaki

OSTEOARTHRITIS AND CARTILAGE, 16(6) 723-732, Jun, 2008 Peer-reviewed
siRNA silencing reveals role of vascular cell adhesion molecule-1 in vascular smooth muscle cell migration

Erik J. Petersen, Toru Miyoshi, Zuobiao Yuan, Satoshi Hirohata, Jin Zhong Li, Weibin Shi, John F. Angle

ATHEROSCLEROSIS, 198(2) 301-306, Jun, 2008 Peer-reviewed
Association of augmentation index of radial pressure wave form with diurnal variation pattern of blood pressure in untreated patients with essential hypertension

Ryoko Shinohata, Takaaki Nakatsu, Yoko Yuki, Aya Nishitani, Keiichi Mashima, Shinji Toyonaga, Hiroko Ogawa, Satoshi Hirohata, Shinichi Usui, Tomoki Kitawaki …

JOURNAL OF HYPERTENSION, 26(3) 535-543, Mar, 2008 Peer-reviewed
Serum interferon-gamma-inducible protein 10 level was increased in myocardial infarction patients, and negatively correlated with infarct size

Kazuya Koten, Satoshi Hirohata, Toru Miyoshi, Hiroko Ogawa, Shinichi Usui, Ryoko Shinohata, Mutsumi Iwamoto, Tomoki Kitawaki, Shozo Kusachi, Kosaku Sakaguchi …

CLINICAL BIOCHEMISTRY, 41(1-2) 30-37, Jan, 2008 Peer-reviewed
Antibodies against heat shock protein 60 derived from Helicobacter pylori: Diagnostic implications in cardiovascular disease

Tomoyuki Okada, Kiyoshi Ayada, Shinichi Usui, Kenji Yokata, Jinhua Cui, Yoshiro Kawahara, Tomoki Inaba, Satoshi Hirohata, Motowo Mizuno, Daisuke Yamamoto …

JOURNAL OF AUTOIMMUNITY, 29(2-3) 106-115, Sep, 2007 Peer-reviewed
Use of plasma B-Type natriuretic peptide level to identify asymptomatic hypertensive patients with abnormal diurnal blood pressure variation profiles: nondippers, extreme dippers, and risers

Takaaki Nakatsu, Ryoko Shinohata, Keiichi Mashima, Yoko Yuki, Aya Nishitani, Shinji Toyonaga, Hiroko Ogawa, Satoshi Hirohata, Shinichi Usui, Shozo Kusachi

HYPERTENSION RESEARCH, 30(7) 651-658, Jul, 2007 Peer-reviewed
Thrombospondin-1 is induced in rat myocardial infarction and its induction is accelerated by ischemia/reperfusion

S Sezaki, S Hirohata, A Iwabu, K Nakamura, K Toeda, T Miyoshi, H Yamawaki, K Demircan, S Kusachi, Y Shiratori …

EXPERIMENTAL BIOLOGY AND MEDICINE, 230(9) 621-630, Oct, 2005 Peer-reviewedCorresponding author
Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status

H Ito, T Kanzawa, T Miyoshi, S Hirohata, S Kyo, A Iwamaru, H Aoki, Y Kondo, S Kondo

HUMAN GENE THERAPY, 16(6) 685-698, Jun, 2005 Peer-reviewed
ADAMTS-9 is synergistically induced by interleukin-1 beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes

K Demircan, S Hirohata, K Nishida, OF Hatipoglu, T Oohashi, T Yonezawa, SS Apte, Y Ninomiya

ARTHRITIS AND RHEUMATISM, 52(5) 1451-1460, May, 2005 Peer-reviewedCorresponding author

Misc.

鉄代謝はNASHと動脈硬化を結ぶ新たなリスク因子になりうるか

本間宏基, 桐原空, 中山日菜子, 柿本麻衣, 藤井萌, 佐藤生弥, 山元修成, 山元修成, 廣畑聡, 渡辺彰吾

日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 54th, 2022
XO阻害薬フェブキソスタットによる抗酸化作用は肝臓・血管系を保護する

柿本麻衣, 藤井萌, 佐藤生弥, 山元修成, 本間宏基, 奥川友葉, 柴田桃里, 小松千尋, 廣畑聡, 渡辺彰吾

日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 53rd, 2021
フルクトース負荷による尿酸上昇がNASHと動脈硬化に及ぼす影響

藤井萌, 柿本麻衣, 山元修成, 佐藤生弥, 本間宏基, 小松千尋, 奥川友葉, 柴田桃里, 廣畑聡, 渡辺彰吾

日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 53rd, 2021
Expression of Osteopontin in non-alcoholic steatohepatitis (NASH) fibrosis

安藤亮典, 畑本早紀子, 中野愛梨, 池村健太郎, 兒玉慎太郎, OPOKU Gabriel, 山元修成, 稲垣純子, 今重之, HATIPOGLU Omer Faruk …

日本結合組織学会学術大会抄録集, 53rd, 2021
国立大学臨書検査技師教育協議会の取り組みと日本臨床検査学教育協議会との連携

廣畑聡

臨床検査学教育, Aug, 2019
BMPR2変異を伴うPAHにおけるSMCのエピジェネティックな変化に対する低酸素の重要な役割(Crucial Role of Hypoxia in Epigenetic Changes of SMCs from PAH with BMPR2 Mutation)

中村一文, 赤木達, 斎藤幸弘, 江尻健太郎, 三好亨, 吉田賢司, 廣畑聡, 伊藤浩

日本循環器学会学術集会抄録集, 83回 OJ10-3, Mar, 2019 Peer-reviewed
変形性関節症関連microRNAの検索並びに解析

大月孝志, オメル・ファルク・ハティポール, 品岡玲, メフメット・ゼイネル・チレッキ, 西村拓人, 浅野恵一, 稲垣純子, 大橋俊孝, 西田圭一郎, 岡田保典 …

日本結合組織学会学術大会プログラム・抄録集, 50回 111-111, Jun, 2018
RNA干渉法による特発性肺線維症に重要な分子のサイレンシング

ハティポール・オメル・ファルク, エユプ・ウチュテペ, グンデゥズ・エスラ, グンデゥズ・メーメット, 大月孝志, 稲垣純子, 廣畑聡

日本結合組織学会学術大会プログラム・抄録集, 50回 146-146, Jun, 2018
炎症性サイトカイン誘導性マトリックス分解酵素発現のイオンチャネルを介した抑制とその機構解析

大月孝志, 品岡玲, 品岡加苗, Mehmet Cilek, Omer Hatipoglu, 西村拓人, 稲垣純子, 西田圭一郎, 廣畑聡

生命科学系学会合同年次大会, 2017年度 [3P-1164], Dec, 2017
がん微小環境の実体がん微小環境におけるバーシカン分解酵素ADAMTSの局在と血管新生におけるバーシカンの意義

浅野恵一, 廣畑聡, 大月孝志, オメル・ファルク・ハティポール, 稲垣純子, 大橋俊孝

日本結合組織学会学術大会プログラム・抄録集, 49回 56-56, Jun, 2017
関節の修復・再生メカニカルストレスの軟骨細胞に及ぼす多彩な作用マトリックス合成促進と炎症性サイトカイン誘導性マトリックス分解活性抑制

大月孝志, 品岡玲, 熊岸加苗, 岡, メフメット・ゼイネル・チレッキ, オメル・ファルク・ハティポール, 稲垣純子, 西田圭一郎, 廣畑聡

日本結合組織学会学術大会プログラム・抄録集, 49回 62-62, Jun, 2017
細胞外マトリックス分解酵素ADAMTS1の多様性

廣畑聡, 稲垣純子, 大月孝志

薬学雑誌, 37(7) 811-814, 2017
変形性関節症へのヒアルロン酸投与、いつ投与すべきか? 動物モデルからの知見

大月孝志, 品岡玲, 熊岸加苗, 河野真優美, 篠原真歩, 浅野恵一, 稲垣純子, 大橋俊孝, 西田圭一郎, 廣畑聡

日本結合組織学会学術大会プログラム・抄録集, 48回 60-60, Jun, 2016
伸展刺激の強度による細胞外マトリックスタンパクおよびマトリックス分解酵素発現への影響

大月孝志, 金道幸子, 長谷川みさ, 稲垣純子, 浅野恵一, 障子友理, 熊岸加苗, 西田圭一郎, 大橋俊孝, 廣畑聡

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [2P0078]-[2P0078], Dec, 2015
関節軟骨造影剤を用いた関節軟骨プロテオグリカンの評価

大橋俊孝, 加来田博貴, 芳谷学, 山田翔也, 大月孝志, 廣畑聡, 二宮善文, 西田圭一郎

日本結合組織学会学術大会プログラム・抄録集, 47回 97-97, May, 2015
ADAMTSによるバーシカン分解と腫瘍内血管新生の関連

浅野恵一, 稲垣純子, 障子友理, Hofmann Matthias, 大月孝志, 廣畑聡, 大橋俊孝

日本結合組織学会学術大会プログラム・抄録集, 47回 114-114, May, 2015
メカニカルストレスが軟骨様細胞の細胞外マトリックス及びマトリックス分解酵素のmRNA発現へ示す効果の検討

大月孝志, 金道幸子, 長谷川みさ, 平田彩, 川地輝幸, 浅野恵一, 稲垣純子, 障子友理, 熊岸加苗, 西田圭一郎 …

日本結合組織学会学術大会プログラム・抄録集, 47回 134-134, May, 2015
新規X線造影剤による変形性膝関節症ラット関節軟骨の高解像度マイクロCT造影

大橋俊孝, 加来田博貴, 芳谷学, 大月孝志, 大野充昭, 山田翔也, 前原亜美, 廣畑聡, 西田圭一郎, 窪木拓男 …

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集, 46回・61回 106-106, Jun, 2014
胎生期ADAMTS1ノックアウトマウスの解析

楠絵里子, 稲垣純子, 大月孝志, 川地輝幸, 平田彩, 浅野恵一, マティアス・ホフマン, 二宮善文, 廣畑聡

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集, 46回・61回 76-76, Jun, 2014
担がんマウスモデルにおけるバーシカン分解の解析

浅野恵一, 稲垣純子, マティアス・ホフマン, 川地輝幸, 平田彩, 大月孝志, 二宮善文, 廣畑聡

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集, 46回・61回 89-89, Jun, 2014

Books and Other Publications

Presentations

204

APP669切断酵素ADAMTS4の同定

金子直樹, 横山雅シャラ, 池村健太郎, 松崎将也, Gabriel Opoku, 伊永章史, 関谷禎規, 岩本慎一, 廣畑聡, 田中耕一, 富田泰輔

第41回日本認知症学会学術集会
ELUCIDATION OF THE TEMPORAL AND SPATIAL MODE OF EXTRACELLULAR MATRIX REMODELING IN VENTRAL WALL DEVELOPMENT.

Gabriel Opoku, Kentaro Ikemura, Ryosuke Ando, Airi Nakano, Ren Takashita, Saeko Hirabayashi, Miki Taga, Omer Faruk Hatipoglu, Junko Inagaki, Satoshi Hirohata
アルツハイマー病血漿バイオマーカー分子APP669-711の産生酵素ADAMTS4の同定

横山雅シャラ, 金子直樹, 松崎将也, 吉澤遥太, Hiroki Naito, Akihito Korenaga, 関谷禎規, 池村健太郎, Gabriel Opoku, 廣畑聡, 岩本慎一, 田中耕一, 富田泰輔

第27回日本病態プロテアーゼ学会
細胞外基質分解酵素を標的とした変形性関節症の新たな治療候補化合物

中野愛梨, 岩本結衣, 池村健太郎, 安藤亮典, オポクガブリエル, 高下蓮, 平林沙江子, 多賀実紀, 勝山惠理, 廣畑聡

第16回日本臨床検査学教育学会学術大会, Aug 18, 2022
ADAMTS4 as an enzyme cleaving at APP669 site.

Naoki Kaneko, Miyabishara Yokoyama, Masaya Matsuzaki, Kentaro Ikemura, Gabriel Opoku, Akihito Korenaga, Sadanori Sekiya, Shinichi Iwamoto, Satoshi Hirohata, Koichi Tanak, Taisuke Tomita

AAIC2022 (Alzheimer's Association International Conference 2022), 2022
Clinical Study about Blood Thiamin (Vitamin B1) Concentration and Its Acute Phase Fluctuation in Patients with Congestive Heart Failure.

飯田倫公, 髙石篤志, 岸之上隆雄, 森久寿, 山地達也, 谷本匡史, 大西伸彦, 廣畑聡

第85回日本循環器学会学術集会
Crucial Role of TRPV2 in the Development of Hypoxia-induced Pulmonary Hypertension.

Nakamura K, Katanosaka Y, Akagi S, Saito Y, Miyoshi T, Yoshida M, Hirohata S, Ito H

第85回日本循環器学会学術集会
Examination of the Relationship between Blood Carnitine Concentration and Clinical Course in Patients with Congestive Heart Failure.
The role of ADAMTS1 in mice embryo development

Gabriel Opoku, Kentaro Ikemura, Ryosuke Ando, Airi Nakano, Shintaro Kodama, Ren Takagishi, Minori Uraki, Junko Inagaki, Satoshi Hirohata

第94回日本生化学会大会, Nov, 2021
XO阻害薬フェブキソスタットによる抗酸化作用は肝臓・血管系を保護する

柿本麻衣, 藤井萌, 佐藤生弥, 山元修成, 本間宏基, 奥川友葉, 柴田桃里, 小松千尋, 廣畑聡, 渡辺彰吾

第53回日本動脈硬化学会学術集会, Oct, 2021
フルクトース負荷による尿酸上昇がNASHと動脈硬化に及ぼす影響

藤井萌, 柿本麻衣, 山元修成, 佐藤生弥, 本間宏基, 小松千尋, 奥川友葉, 柴田桃里, 廣畑聡, 渡辺彰吾

第53回日本動脈硬化学会学術集会, Oct, 2021
関節を構成する細胞への細胞外分泌小胞取り込みの検討

兒玉慎太郎, 池村健太郎, 安藤亮典, 中野愛梨, Opoku Gabriel, 高下蓮, 浦木美能理, 稲垣純子, 古松毅之, 廣畑聡

第8回日本細胞外小胞学会, Oct, 2021
非アルコール性脂肪肝炎線維化におけるオステオポンチンの発現

安藤亮典, 畑本早紀子, 中野愛梨, 池村健太郎, 兒玉慎太郎, オポク・ガブリエル, 山元修成, 稲垣純子, 今重之, ハティポール・オメル・ファルク, 渡辺彰吾, 廣畑聡

第53回日本結合組織学会学術大会, Jun, 2021
Crucial Role of TRPV2 in the Development of Hypoxia-induced Pulmonary Hypertension

Mar, 2021
Supplementation of Omega-3 PUFAs could improve long term prognosis after PCI in patients without hyperlipidemia and diabetes.

EAS congress, 2018
The Westerizaton of Life Style and Atherosclerosis in Japan –The Balance of EPA and AA-

EAS congress, 2018
炎症性サイトカイン誘導性マトリックス分解酵素発現のイオンチャネルを介した抑制とその機構解析

2017 年度生命科学系学会合同年次大会, 2017
Molecular and biochemical analysis of HYBID (HYaluronan-Binding protein Involved in hyaluronan Depolymerization) gene expression.

Ohtsuki T, Yoshida H, Shinaoka A, Kumagishi-Shinaoka K, Cilek MZ, Hatipoglu OF, Inagaki J, Nishida K,Okada Y, Hirohata S.

第30回日本軟骨代謝学会, 2017
Inflammatory cytokine-induced matrix degrading enzymes expression were attenuated by mechanical stress through transient receptor potential cation channel

ConBio2017, 2017
リンパ管内皮細胞に対するADAMTS1の作用とシグナル伝達

稲垣純子, 高橋克之, 小川弘子, Hatipoglu Omer F., Zeynel Cilek Mehmet, 小比賀真就, 廣畑聡, 二宮善文

第８５回日本生化学会大会, 2012

Professional Memberships

Research Projects

Mechanism of hyaluronan-degrading enzyme HYBID expression by chondrocytes and its regulation by microRNAs

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
やせ型非アルコール性脂肪肝炎と動脈硬化性疾患を仲介する鉄代謝の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2026

渡辺彰吾, 大原利章, 家森幸男, 北森一哉, 薗田邦博, 廣畑聡
Decipher cell-cell interactions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2025
Homeostatic effect of improvement candidate drug targeting IL-33

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Molecular mechanism of liver fibrosis progression by CCR2-positive macrophages in NASH

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Inagaki Junko
Establishment of molecular mechanism for moderate alcohol intake to prevent atherosclerosis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

USUI Shinichi
Cartilage protection by mechanical stress - changes of Exosome contents-

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2021
Construction of Academic Foundations and Development of a Curriculum for the Creation of Medical Ethics of Hansen's disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

KONDO Makiko
Comprehensive analysis of exosomes in cartilage and approach to the new strategy for osteoarthritis therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

HIROHATA SATOSHI
Development of new therapeutic drug for osteoarthritis by drug repositioning

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

HATIPOGLU OMER FARUK
Regulatory system of microRNA and ADAM12 expression in the process of joint remodeling

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Nishida Keiichiro
Challenge for liquid biopsy of osteoarthritis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019

HIROHATA SATOSHI
Analysis of cartilage protection by mechanical stress -miRNA and extracellular vesicles functions in osteoarthritis-

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Ohtsuki Takashi
The role of apoE-rich HDL in lifestyle diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

USUI SHINICHI, SHINOHATA Ryoko
Establishment of in vivo imaging and quantification of articular cartilage by using a cartilage-specific probe.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Oohashi Toshitaka, HIROHATA Satoshi, OHTSUKI Takakashi, ASZDI Attila
Integrated analysis of microRNAs that regulate cartilage damage and its functional analysis in chondrocytes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

HIROHATA SATOSHI, NINOMIYA Yoshifumi
Mechanobiology of tumor interstitial fluid pressure, angiogenesis, lymphangiogenesis, and Extracellular Matrix (ECM)

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Inagaki Junko, NARUSE KEIJI
Molecular biological analysis of rehabilitation on osteoarthritis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Kumagishi Kanae, HIROHATA Satoshi, OHTSUKI Takashi, SHINAOKA Akira, Kawamura Kenji, SAKAI Takahumi
The role of endocytosis in oateoarhthritis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

HIROHATA Satoshi, YAMADA Hiroshi, OHTSUKI Takashi
The role of ADAMTS in cardiovascular disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

KUSACHI Shozo, HIROHATA Satoshi, OGAWA Hiroko

Industrial Property Rights

特許第6161828号がんの非ヒトモデル動物及びその作製方法、がん幹細胞及びその製造方法

妹尾昌治, 笠井智成, 岩崎良章, 大原利章, 廣畑聡, 加来田博貴
特許第5651890号再灌流療法の治療効果を判定するキット

廣畑聡, 臼井真一, 草地省藏
特許第5493231号新規ＤＮＡ断片およびその用途

廣畑聡, 二宮善文, 草地省藏, オメル、ファルクハティポール
特許第5467742号 ECPを有効成分とする左室リモデリングの予防及び治療剤。

妹尾昌治, 多田宏子, 福田隆之, 廣畑聡, 丸山昌彦, 草地省蔵, 二宮善文, 五十嵐貢一
特許第4843767号がん細胞特異的遺伝子発現法を用いた血管新生阻害薬

廣畑聡, 三好亨, 土井正行, 小川弘子, 二宮善文
特開2011-020923 動脈硬化の診断及び治療

廣畑聡, 幡中邦彦, 小川弘子, 草地省蔵, 二宮善文, 五十嵐貢一
WO2010-055867 再灌流療法の治療効果を判定する方法

廣畑聡, 臼井真一, 草地省藏
特許第4195492号急性虚血性疾患の診断薬

廣畑聡, 臼井真一, 草地省蔵
特開2007-114930 物理現象解析支援方法、物理現象解析支援システム、物理現象解析支援プログラム

中吉英夫, 廣畑賢治, 久野勝美, 青木秀夫
特開2007-108843 半導体装置設計支援方法、半導体装置設計支援システム、半導体装置設計支援プログラム

中吉英夫, 廣畑賢治, 青木秀夫
再灌流療法の治療効果を判定する方法
再灌流療法の治療効果を判定する方法
ＥＣＰを有効成分とする左室リモデリングの予防及び治療剤
ＥＣＰを有効成分とする左室リモデリングの予防及び治療剤
ＥＣＰを有効成分とする左室リモデリングの予防及び治療剤
新規ＤＮＡ断片およびその用途
新規ＤＮＡ断片およびその用途
動脈硬化の診断及び治療
がん細胞特異的遺伝子発現法を用いた血管新生阻害薬
がん細胞特異的遺伝子発現法を用いた血管新生阻害薬

Academic Activities

第85回日本循環器学会学術集会座長

Panel moderator, session chair, etc.

Mar 26, 2021 - Mar 28, 2021

Social Activities

岡山大学先端研究講座「細胞が刺激に応答するしくみ」

Lecturer

岡山大学, 公開講座, Nov 5, 2021 - Nov 5, 2021

Other

国際協力

2021

UNCTAD短期受入研修生を担当

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