2019年
An Update on the Role of Adipose Tissues in Psoriasis.
Frontiers in immunology
- ,
- ,
- ,
- 巻
- 10
- 号
- 開始ページ
- 1507
- 終了ページ
- 1507
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3389/fimmu.2019.01507
Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cross-talk between adipocytes and the immune system via various mediators such as adipokines could explain how obesity contributes to psoriasis. The effects of obesity on adipocytes include upregulation of pro-inflammatory adipokines such as leptin and resistin, downregulation of anti-inflammatory adipokine, and also the stimulation of pro-inflammatory cytokine production by macrophages. This article provides an update on the role of adipose tissues in psoriasis.
- リンク情報
- ID情報
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- DOI : 10.3389/fimmu.2019.01507
- PubMed ID : 31316526
- PubMed Central 記事ID : PMC6609873