2005年6月
Dynamic characteristics of transient responses
JOURNAL OF BIOCHEMISTRY
- ,
- ,
- 巻
- 137
- 号
- 6
- 開始ページ
- 659
- 終了ページ
- 663
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1093/jb/mvi084
- 出版者・発行元
- JAPANESE BIOCHEMICAL SOC
Transient responses of signaling molecules are seen in a wide variety of cellular processes that are mediated by distinct molecular mechanisms. Although transient responses might intuitively be thought to depend on the absolute concentration of growth factors or the intensity of stimulation, we here introduce that some transient responses are prompted by temporal rate of increase of stimulation, rather than intensity of stimulation, by three independent mechanisms. These include the Ras system with fast activation and slow inactivation, the ERK-dependent negative feedback loop system, and the receptor degradation system, all of which can be commonly seen in various signaling networks. In addition, we show the distinct transient and steady state characteristics of these systems.
- リンク情報
- ID情報
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- DOI : 10.1093/jb/mvi084
- ISSN : 0021-924X
- PubMed ID : 16002986
- Web of Science ID : WOS:000230308900002