2018年11月
Enantioselective Desymmetrization of 1,3-Diols by a Chiral DMAP Derivative
CHEMISTRY LETTERS
- ,
- ,
- ,
- 巻
- 47
- 号
- 11
- 開始ページ
- 1360
- 終了ページ
- 1363
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1246/cl.180697
- 出版者・発行元
- CHEMICAL SOC JAPAN
We developed an enantioselective desymmetrization of 1,3-diols by a chiral N,N-dimethyl-4-aminopyridine (DMAP) derivative containing a 1,1'-binaphthyl with tert-alcohol units. The reactions required only 0.1 mol % of catalyst and showed moderate to high chemoselectivity (monoacylation vs. diacylation) and enantioselectivity (14 examples, up to 95:5 er). Several control experiments revealed that diol units in both the substrate and the catalyst are important to achieve high enantioselectivity.
- リンク情報
- ID情報
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- DOI : 10.1246/cl.180697
- ISSN : 0366-7022
- eISSN : 1348-0715
- Web of Science ID : WOS:000450196800006