2015年11月
Placental extracts induce the expression of antioxidant enzyme genes and suppress melanogenesis in B16 melanoma cells
NATURAL PRODUCT RESEARCH
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- 巻
- 29
- 号
- 22
- 開始ページ
- 2103
- 終了ページ
- 2106
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1080/14786419.2014.986660
- 出版者・発行元
- TAYLOR & FRANCIS LTD
One of the activities of placental extracts (PEs) is skin-whitening effect, but the physiological and genetic mechanism for this effect has not yet been clarified. Here, we focus on PE as a regulator of antioxidant enzyme genes. Porcine PE was prepared, and its activity was investigated in B16 melanoma cells. PE treatment decreased the melanin content of UV-irradiated B16 cells in a dose-dependent manner. PE directly reduced the enzyme activity of tyrosinase in a cell-free assay. In addition, PE treatment increased the gene expression of cytosolic superoxide dismutase (SOD-1), extracellular SOD (SOD-3) and catalase but did not affect the expression of tyrosinase. Moreover, PE protected the B16 cells from H2O2-induced cell death. Taken together, our data suggest that PEs could play a role not only as a suppressor of melanin synthesis but also as a regulator of antioxidant genes and might protect the skin against oxidative stress.
- リンク情報
- ID情報
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- DOI : 10.1080/14786419.2014.986660
- ISSN : 1478-6419
- eISSN : 1478-6427
- PubMed ID : 25435062
- Web of Science ID : WOS:000361532500008