Song-iee Han - My portal

Profile Information

Affiliation: University of Tsukuba

J-GLOBAL ID: 201801016926108419
researchmap Member ID: B000339631

Research Interests

Research Areas

Research History

Feb, 2019 - Present

International Institute for Integrative Sleep Medicine, University of Tsukuba
Apr, 2014 - Jan, 2019

Faculty of Medicine, University of Tsukuba
Apr, 2011 - Mar, 2014

日本学術振興会特別研究員RPD, 生命医科学研究科 / 生命環境系, 横浜市立大学 / 筑波大学
Apr, 2006 - Mar, 2011

Faculty of Life and Environmental Sciences, University of Tsukuba
Apr, 2004 - Mar, 2006

Graduate School of Biological Sciences, Nara Institute of Science and Technology

Education

Apr, 1998 - Mar, 2004

Tokyo Institute of Technology
Mar, 1994 - Feb, 1998

自然科学科, 梨花女子大学

Papers

The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice

Masaya Araki, Yoshimi Nakagawa, Asayo Oishi, Song-iee Han, Yunong Wang, Kae Kumagai, Hiroshi Ohno, Yuhei Mizunoe, Hitoshi Iwasaki, Motohiro Sekiya …

International Journal of Molecular Sciences, 19(7) E2148, Jul, 2018 Peer-reviewed
Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance

Hiroshi Ohno, Takashi Matsuzaka, Nie Tang, Rahul Sharma, Kaori Motomura, Takuya Shimura, Aoi Satoh, Song-Iee Han, Yoshinori Takeuchi, Yuichi Aita …

Endocrinology, 159(6) 2308-2323, Jun 1, 2018 Peer-reviewed
Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα

Yuta Yamamoto, Kenta Takei, Sundaram Arulmozhiraja, Vladimir Sladek, Naoya Matsuo, Song-iee Han, Takashi Matsuzaka, Motohiro Sekiya, Takaki Tokiwa, Mitsuo Shoji …

Biochemical and Biophysical Research Communications, 499(2) 239-245, May 5, 2018 Peer-reviewed
Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding beta-Cell Mass and Increasing Insulin Secretory Capacity

Hui Zhao, Takashi Matsuzaka, Yuta Nakano, Kaori Motomura, Nie Tang, Tomotaka Yokoo, Yuka Okajima, Song-iee Han, Yoshinori Takeuchi, Yuichi Aita …

DIABETES, 66(7) 1833-1846, Jul, 2017 Peer-reviewed
Selective peroxisome proliferator-activated receptor-alpha modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-alpha pathway and improves lipid metabolism in mice

Kenta Takei, Song-iee Han, Yuki Murayama, Aoi Satoh, Fusaka Oikawa, Hiroshi Ohno, Yoshinori Osaki, Takashi Matsuzaka, Motohiro Sekiya, Hitoshi Iwasaki …

JOURNAL OF DIABETES INVESTIGATION, 8(4) 446-452, Jul, 2017 Peer-reviewed
Effects of K-877, a novel selective PPAR alpha modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice

Kenta Takei, Yoshimi Nakagawa, Yunong Wang, Song-iee Han, Aoi Satoh, Motohiro Sekiya, Takashi Matsuzaka, Hitoshi Shimano

JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(4) 214-222, Apr, 2017 Peer-reviewed
CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα

Yoshimi Nakagawa, Aoi Satoh, Hitomi Tezuka, Song-iee Han, Kenta Takei, Hitoshi Iwasaki, Shigeru Yatoh, Naoya Yahagi, Hiroaki Suzuki, Yasumasa Iwasaki …

Scientific Reports, 6 39182, Dec, 2016 Peer-reviewed
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

Takuya Kikuchi, Kana Orihara, Fusaka Oikawa, Song-iee Han, Motoko Kuba, Kanako Okuda, Aoi Satoh, Yoshinori Osaki, Yoshinori Takeuchi, Yuichi Aita …

MOLECULAR METABOLISM, 5(11) 1092-1102, Nov, 2016 Peer-reviewed
Phosphorylation of MafA enhances interaction with Beta2/NeuroD1

Song-iee Han, Yukino Tsunekage, Kohsuke Kataoka

ACTA DIABETOLOGICA, 53(4) 651-660, Aug, 2016 Peer-reviewed
Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

Noriko Suzuki-Kemuriyama, Takashi Matsuzaka, Motoko Kuba, Hiroshi Ohno, Song-iee Han, Yoshinori Takeuchi, Masaaki Isaka, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yatoh …

PLOS ONE, 11(6) e0157580, Jun, 2016 Peer-reviewed
Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

Yoshimi Nakagawa, Fusaka Oikawa, Seiya Mizuno, Hiroshi Ohno, Yuka Yagishita, Aoi Satoh, Yoshinori Osaki, Kenta Takei, Takuya Kikuchi, Song-iee Han …

SCIENTIFIC REPORTS, 6 27857, Jun, 2016 Peer-reviewed
Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model

Motoko Kuba, Takashi Matsuzaka, Rie Matsumori, Ryo Saito, Naoko Kaga, Hikari Taka, Kei Ikehata, Naduki Okada, Takuya Kikuchi, Hiroshi Ohno …

SCIENTIFIC REPORTS, 5 17604, Dec, 2015 Peer-reviewed
Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1

Song-iee Han, Yukino Tsunekage, Kohsuke Kataoka

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 411(C) 113-120, Aug, 2015 Peer-reviewed
Hepatic rRNA Transcription Regulates High-Fat-Diet-Induced Obesity

Shohei Oie, Kazuya Matsuzaki, Wataru Yokoyama, Shinji Tokunaga, Tsuyoshi Waku, Song-Iee Han, Naoya Iwasaki, Aya Mikogai, Kayoko Yasuzawa-Tanaka, Hiroyuki Kishimoto …

CELL REPORTS, 7(3) 807-820, May, 2014 Peer-reviewed
Estrogen Receptor Ligands Ameliorate Fatty Liver Through a Nonclassical Estrogen Receptor/Liver X Receptor Pathway in Mice

Song-iee Han, Yoko Komatsu, Akiko Murayama, Knut R. Steffensen, Yoshimi Nakagawa, Yuka Nakajima, Michiko Suzuki, Shohei Oie, Paolo Parini, Lise-Lotte Vedin …

HEPATOLOGY, 59(5) 1791-1802, May, 2014 Peer-reviewed
ATF2 Interacts with beta-Cell-enriched Transcription Factors, MafA, Pdx1, and Beta2, and Activates Insulin Gene Transcription

Song-iee Han, Kunio Yasuda, Kohsuke Kataoka

JOURNAL OF BIOLOGICAL CHEMISTRY, 286(12) 10449-10456, Mar, 2011 Peer-reviewed
SUMOylation negatively regulates transcriptional and oncogenic activities of MafA

Kenichi Kanai, Hasan Mahmud Reza, Akiyo Kamitani, Yuri Hamazaki, Song-iee Han, Kunio Yasuda, Kohsuke Kataoka

GENES TO CELLS, 15(9) 971-982, Sep, 2010 Peer-reviewed
MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3

Song-iee Han, Shinsaku Aramata, Kunio Yasuda, Kohsuke Kataoka

MOLECULAR AND CELLULAR BIOLOGY, 27(19) 6593-6605, Oct, 2007 Peer-reviewed
Roles and regulation of transcription factor MafA in islet β-cells

Shinsaku Aramata, Song-Iee Han, Kohsuke Kataoka

Endocrine Journal, 54(5) 659-666, 2007 Peer-reviewed
Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1

S Aramata, S Han, K Yasuda, K Kataoka

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1730(1) 41-46, Jul, 2005 Peer-reviewed

Presentations

MafAはリン酸によりBeta2/NeuroD1との相互作用が亢進する

韓松伊, 常陰幸乃, 片岡浩介

第39回日本分子生物学会, Dec 2, 2016
Gata3はSP1との相互作用を介してMafB及びGcm2と協調的に副甲状腺ホルモン遺伝子の発現を活性化する

韓松伊, 常陰幸乃, 片岡浩介

第38回日本分子生物学会・第88回日本生化学大会合同大会, Dec 2, 2015
MafAのリン酸化によるインスリン遺伝子転写制御と膵臓β細胞疲弊

韓松伊, 常陰幸乃, 片岡浩介

転写サイクル・転写代謝システム・転写研究会共催「若手ワークショップ2014」, Jan, 2014
核内受容体ER/LXRクロストークによる脂質代謝制御機構の解明

韓松伊, 鈴木美智子, 村山明子, 柳澤純

転写研究会・転写サイクル・転写代謝システム共催「若手ワークショップ＠鬼怒川」, Jan, 2013
Non-classical ER/LXR pathway in lipid metabolism

SI. Han, S. Suzuki, A. Murayama, J. Yanagisawa

Jul, 2012
ER-LXR cross-talkによる転写制御メカニズムの解析

韓松伊, 小松蓉子, 柳澤純

第32回日本分子生物学会年会, Dec, 2009
ER-LXR cross talk and lipid metabolism.

SI. Han, Y. Komatsu, J. Yanagisawa

University of Tsukuba and SKKU Joint Symposium in Biological Sciences, Nov, 2009
ER-LXR cross-talkによる転写制御メカニズムの解析

韓松伊, 小松蓉子, 仲島由佳, 柳澤純

第31回日本分子生物学会・第81回日本生化学大会合同大会, Dec, 2008
Regulation of insulin gene expression by islet beta-cell specific transcription factor MafA post-translational modification.

SI. Han, S. Aramata, K. Kataoka

Keystone Symposia (Towards Understanding Islet Biology), Feb, 2006
転写因子MafAのリン酸化によるインスリン遺伝子発現調節機構の解析

韓松伊, 荒俣晋作, 神谷明代, 安田國雄, 片岡浩介

文部科学省特定領域研究「遺伝情報発現におけるDECODEシステムの解明」冬のワークショップ, Jan, 2006
転写因子MafAのリン酸化によるインスリン遺伝子発現調節機構の解析

韓松伊, 荒俣晋作, 神谷明代, 安田國雄, 片岡浩介

第28回日本分子生物学会年会, Dec, 2005
アデノ随伴ウィルスRep68タンパク質は14-3-3タンパク質と相互作用する

韓松伊, 川野雅章, 山本法明, 片岡浩介, 中西章, 半田宏

第51回日本ウィルス学会学術集会, Nov, 2003
アデノ随伴ウィルスRepタンパク質と相互作用する細胞性因子の探索

韓松伊, 川野雅章, 石津健一郎, 金刺進之介, 金洋水, 渡辺肇, 半田宏

第49回日本ウィルス学会学術集会, Nov, 2001

Professional Memberships

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Research Projects

新規SREBP-1プロテアーゼR4によるlipid-sensing分子機構の解明

基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

韓松伊
SREBP-1活性化を制御する新奇プロテアーゼによる新たな脂質代謝制御機構の解明

基盤研究(C), 日本学術振興会, Apr, 2016 - Mar, 2019

韓松伊
エネルギー代謝における転写因子複合体形成と遺伝子発現制御

科研費研究活動スタート支援, 日本学術振興会, Apr, 2014 - Mar, 2016

韓松伊