2019年12月17日
Universal phase behaviors of intracellular lipid droplets
Proceedings of the National Academy of Sciences of the United States of America
- ,
- 巻
- 116
- 号
- 51
- 開始ページ
- 25440
- 終了ページ
- 25445
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1073/pnas.1916248116
- 出版者・発行元
- NATL ACAD SCIENCES
© 2019 National Academy of Sciences. All rights reserved. Lipid droplets are cytoplasmic microscale organelles involved in energy homeostasis and handling of cellular lipids and proteins. The core structure is mainly composed of two kinds of neutral lipids, triglycerides and cholesteryl esters, which are coated by a phospholipid monolayer and proteins. Despite the liquid crystalline nature of cholesteryl esters, the connection between the lipid composition and physical states is poorly understood. Here, we present a universal intracellular phase diagram of lipid droplets, semiquantitatively consistent with the in vitro phase diagram, and reveal that cholesterol esters cause the liquid–liquid crystal phase transition under near-physiological conditions. We moreover combine in vivo and in vitro studies, together with the theory of confined liquid crystals, to suggest that the radial molecular alignments in the liquid crystallized lipid droplets are caused by an anchoring force at the droplet surface. Our findings on the phase transition of lipid droplets and resulting molecular organization contribute to a better understanding of their biological functions and diseases.
- リンク情報
-
- DOI
- https://doi.org/10.1073/pnas.1916248116
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/31772016
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000503281500020&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076717547&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85076717547&origin=inward
- ID情報
-
- DOI : 10.1073/pnas.1916248116
- ISSN : 0027-8424
- eISSN : 1091-6490
- PubMed ID : 31772016
- SCOPUS ID : 85076717547
- Web of Science ID : WOS:000503281500020