2002年5月
Subtle mutations in the cysteine region of HIV-1 Vif drastically alter the viral replication phenotype
MICROBES AND INFECTION
- ,
- ,
- ,
- ,
- ,
- 巻
- 4
- 号
- 6
- 開始ページ
- 621
- 終了ページ
- 624
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S1286-4579(02)01580-0
- 出版者・発行元
- EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Mutations were introduced into the region encoding the two cysteine and nearby amino acid residues of human immunodeficiency virus type I (HIV-1) Vif protein and, 12 single-amino-acid viral mutants were constructed. Determination of their growth characteristics in two lymphocytic cell lines revealed that only a single amino acid change in the cysteine region greatly altered the replication phenotype. In particular, the four mutants of amino acid 132 of Vif were grouped into three categories on the basis of their growth potentials. These results indicate that the cysteine region of Vif is critical for the cell-dependent replication efficiency of HIV-1. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/S1286-4579(02)01580-0
- ISSN : 1286-4579
- PubMed ID : 12048031
- Web of Science ID : WOS:000176253100005