2014年1月
ビタミンKと骨代謝
Vitamins
- ,
- 巻
- 88
- 号
- 1
- 開始ページ
- 18
- 終了ページ
- 24
- 記述言語
- 日本語
- 掲載種別
- DOI
- 10.20632/vso.88.1_18
- 出版者・発行元
- 公益社団法人 日本ビタミン学会
Vitamin K (VK) is a fat-soluble vitamin that is essential for blood coagulation as well as bone metabolism. VK consists of 3 forms due to the difference of side chains bound to naphtoquinone ring: VK_1 (phylloquinone), VK_2 (menaquinone) and, VK_3 (menadione). In Japan, VK_2 is clinically used as a therapeutic agent for osteoporosis. VK functions as a co-factor of VK-dependent γ-glutamyl carboxylase (GGCX) in mediating post-translational modifications. As GGCX-dependent γ-carboxylated (Gla) proteins expressed in bone, osteocalcin (OC) and matrix Gla protein (MGP) are known to play modulatory roles in bone metabolism. On the other hand, VK_2 also regulates the transcription of bone-related genes in osteoblasts through activating steroid X receptor (SXR)/pregnane X receptor (PXR), as well as enhancing the phosphorylation of protein kinase A (PKA). Recent studies have revealed that osteoblast-derived OC also exerts a hormone-like action that controls bone metabolism and energy metabolism. Overall, VK is an essential nutrient for bone metabolism through modulating multiple signaling pathways mediated by GGCX, SXR, PKA, and VK-dependent proteins
- リンク情報
- ID情報
-
- DOI : 10.20632/vso.88.1_18
- ISSN : 0006-386X
- CiNii Articles ID : 110009767428
- CiNii Books ID : AN00207833