Background: Female is reported to be preferred CRT compared to male. However, precise effect of gender difference on clinical outcomes is not well known. Methods: We investigated 651 patients from CUBIC study and divided into two groups, 197 female (F group), 454 male (M group). Results: Mean follow up were 22+/15 months. F group was older (71 years vs. 68 years, p=0.01) and more likely to have wide QRS (155 ms vs. 148 ms, p=0.027) and non-ischemic etiology (83% vs. 62%, p<0.0001). M group was more likely to have diabetic (39% vs. 20%, p<0.0001), renal failure (32% vs. 17%, p<0.0001), AF (33% vs. 25%, p=0.036), VT/VF (19% vs. 12%, p=0.027) and larger LV (64 mm vs. 60 mm, p<0.0001). CRT-D were more common in M group (65% vs. 47%, p<0.0001). NYHA class (F group: 2.9 vs. M group: 2.9) and LVEF (F group: 29% vs. M group: 28%) were similar. There was no difference in NYHA class (2.0 vs. 2.2, p=ns) and responder rate (63% vs. 62%, p=ns) at 6-month. The event free survival rates from combined death and heart failure hospitalization, ventricular arrhythmic events were significantly higher in F group (71% vs. 60% at 2-year, Log-rank p=0.038, 79% vs. 67% at 2-year, Log-rank p=0.001, respectively). Conclusion: Female has fewer commodities and seems to have preferable clinical outcomes after CRT.