A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (chi(2) = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for Multiple testing (corrected P = 0.192). The present results Suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia ill this population. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.