2007年
Preparation of tiny biodegradable capsules using electrocapillary emulsification
JOURNAL OF MICROENCAPSULATION
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- 巻
- 24
- 号
- 8
- 開始ページ
- 777
- 終了ページ
- 786
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1080/02652040701644752
- 出版者・発行元
- TAYLOR & FRANCIS LTD
Conditions for preparing tiny biodegradable capsules were examined using electrocapillary emulsification that allows one to prepare monodisperse emulsions with ease by applying a DC potential between oil and water phases without mechanical agitation. The results obtained showed that a 1:4 mixture of polysorbate 80 (TO-10), a hydrophilic non-ionic surfactant, and sorbitan monooleate (SO-10), an oleophilic surfactant, is appropriate as the surfactant to be added to oil phase, cyclohexane is acceptable as the oil phase and 1000 V is optimum as the DC potential to be applied. The capsules prepared had sizes ranging from 100 - 300 nm and a surface roughness of similar to 10nm and degraded in model intestinal juice more easily and rapidly than in model gastric juice. In addition, the capsules containing lactoferrin, an anti-carcinogenic protein, were found to keep 12.5% of the protein used in encapsulation without losing its activity.
- リンク情報
- ID情報
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- DOI : 10.1080/02652040701644752
- ISSN : 0265-2048
- Web of Science ID : WOS:000251930200006