2017年12月
Population-based biobank participants' preferences for receiving genetic test results.
Journal of human genetics
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- 巻
- 62
- 号
- 12
- 開始ページ
- 1037
- 終了ページ
- 1048
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/jhg.2017.81
- 出版者・発行元
- NATURE PUBLISHING GROUP
There are ongoing debates on issues relating to returning individual research results (IRRs) and incidental findings (IFs) generated by genetic research in population-based biobanks. To understand how to appropriately return genetic results from biobank studies, we surveyed preferences for returning IRRs and IFs among participants of the Tohoku Medical Megabank Project (TMM). We mailed a questionnaire to individuals enrolled in the TMM cohort study (Group 1; n=1031) and a group of Tohoku region residents (Group 2; n= 2314). The respondents were required to be over 20 years of age. Nearly 90% of Group 1 participants and over 80% of Group 2 participants expressed a preference for receiving their genetic test results. Furthermore, over 60% of both groups preferred to receive their genetic results 'from a genetic specialist.' A logistic regression analysis revealed that engaging in 'health-conscious behaviors' (such as regular physical activity, having a healthy diet, intentionally reducing alcohol intake and/ or smoking and so on) was significant, positively associated with preferring to receive their genetic test results (odds ratio=2.397 (Group 1) and 1.897 (Group 2)). Our findings provided useful information and predictors regarding the return of IRRs and IFs in a population-based biobank.
- リンク情報
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- DOI
- https://doi.org/10.1038/jhg.2017.81
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28794501
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709720
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000416353600006&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1038/jhg.2017.81
- ISSN : 1434-5161
- eISSN : 1435-232X
- PubMed ID : 28794501
- PubMed Central 記事ID : PMC5709720
- Web of Science ID : WOS:000416353600006