Toshiki Wada

Profile Information

ORCID ID: https://orcid.org/0000-0002-6208-0590
J-GLOBAL ID: 200901037565142339
Researcher ID: D-2420-2013
researchmap Member ID: 5000050282

External link: http://www.kanazawa-med.ac.jp/~serol/

Papers

PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon

Xinquan Yang, Toshiki Yabe-Wada, Jia Han, Fumiji Saito, Chie Ogasawara, Sohsuke Yamada, Nobuyuki Onai

International Immunology, Jan 25, 2023 Peer-reviewedLead author
Detailed Structure of Mouse Interferon α2 and Its Interaction with Sortilin

Honoka Watanabe, Toshiki Yabe-Wada, Nobuyuki Onai, Masaki Unno

The Journal of Biochemistry, Mar 25, 2021 Peer-reviewedLead author
PCBP2 posttranscriptionally regulates sortilin expression by binding to a C-rich element in its 3′ UTR

Toshiki Yabe-Wada, Caroline C Philpott, Nobuyuki Onai

FEBS Open Bio, 10(3) 407-413, Mar, 2020 Peer-reviewedLead authorCorresponding author
Crystal structure of the ligand-free form of the Vps10 ectodomain of dimerized Sortilin at acidic pH.

Toshiki Yabe-Wada, Shintaro Matsuba, Masaki Unno, Nobuyuki Onai

FEBS Letters, 592 2647-2657, Aug, 2018 Peer-reviewedLead authorCorresponding author
Identification of Secretory Leukoprotease Inhibitor As an Endogenous Negative Regulator in Allergic Effector Cells

Shintaro Matsuba, Toshiki Yabe-Wada, Kazuya Takeda, Tetsuya Sato, Mikita Suyama, Toshiyuki Takai, Toshiaki Kikuchi, Toshihiro Nukiwa, Akira Nakamura

Frontiers in Immunology, 8 1538, 2017 Peer-reviewed
Monomeric Form of Peptidylarginine Deiminase Type I revealed by X-ray Crystallography and Small-Angle X-ray Scattering

Shinya Saijo, Anna Nagai, Saya Kinjo, Ryutaro Mashimo, Megumi Akimoto, Kenji Kizawa, Toshiki Yabe-Wada, Nobutaka Shimizu, Hidenari Takahara, Masaki Unno

Journal of Molecular Biology, 428(15)(15) 3058-3073, Jul, 2016 Peer-reviewed
好酸球、マスト細胞、好塩基球好酸球におけるSLPIの制御機構の解明

松葉慎太郎, 和田俊樹, 武田和也, 佐藤哲也, 須山幹太, 高井俊行, 中村晃

アレルギー, 65(4-5) 558-558, May, 2016
TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin

Toshiki Yabe-Wada, Shintaro Matsuba, Kazuya Takeda, Tetsuya Sato, Mikita Suyama, Yasuyuki Ohkawa, Toshiyuki Takai, Haifeng Shi, Caroline C. Philpott, Akira Nakamura

Scientific Reports, 6 26566, May, 2016 Peer-reviewedLead authorCorresponding author
A critical role of Dectin-1 in hypersensitivity pneumonitis

Mari Higashino-Kameda, Toshiki Yabe-Wada, Shintaro Matsuba, Kazuya Takeda, Kazushi Anzawa, Takashi Mochizuki, Koichi Makimura, Shinobu Saijo, Yoichiro Iwakura, Hirohisa Toga …

Inflammation research, 65(3)(3) 235-244, Mar, 2016 Peer-reviewed
TLR9シグナルの新規制御分子Sortilinの機能解析

和田俊樹, 武田和也, 松葉慎太郎, 中村晃, 佐藤哲也, 須山幹太, 大川恭行, 高井俊行

金沢医科大学雑誌, 39(2) 45-45, Oct, 2014
Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.

Avery G Frey, Anjali Nandal, Jong Hwan Park, Pamela M Smith, Toshiki Yabe, Moon-Suhn Ryu, Manik C Ghosh, Jaekwon Lee, Tracey A Rouault, Myung Hee Park …

Proceedings of the National Academy of Sciences of the United States of America, 111(22) 8031-8036, May, 2014 Peer-reviewed
好塩基球・好酸球におけるSLPIの制御機構の解明

松葉慎太郎, 和田俊樹, 武田和也, 佐藤哲也, 須山幹太, 高井俊行, 中村晃

アレルギー, 62(9-10) 1407-1407, Oct, 2013
Each Member of the Poly-r(C)-binding Protein 1 (PCBP) Family Exhibits Iron Chaperone Activity toward Ferritin.

Sebastien Leidgens, Kimberly Z Bullough, Haifeng Shi, Fengmin Li, Minoo Shakoury-Elizeh, Toshiki Yabe, Poorna Subramanian, Emory Hsu, Navin Natarajan, Anjali Nandal …

The Journal of Biological Chemistry, 288(24) 17791-17802, Jun, 2013 Peer-reviewed
Regulation of plasmacytoid dendritic cell responses by PIR-B.

Yoshiya Mitsuhashi, Akira Nakamura, Shota Endo, Kazuya Takeda, Toshiki Yabe-Wada, Toshihiro Nukiwa, Toshiyuki Takai

Blood, 120(16) 3256-3259, Sep, 2012 Peer-reviewed
Arabidopsis cytosolic Nbp35 homodimer can assemble both [2Fe-2S] and [4Fe-4S] clusters in two distinct domains.

Hirokazu Kohbushi, Yumi Nakai, Shingo Kikuchi, Toshiki Yabe, Hiroshi Hori, Masato Nakai

Biochemical and Biophysical Research Communications, 378(4) 810-815, Jan, 2009 Peer-reviewed
Structural analysis of Arabidopsis CnfU protein: an iron-sulfur cluster biosynthetic scaffold in chloroplasts.

Toshiki Yabe, Eiki Yamashita, Akihiro Kikuchi, Kozo Morimoto, Atsushi Nakagawa, Tomitake Tsukihara, Masato Nakai

Journal of Molecular Biology, 381(1) 160-173, Aug, 2008 Peer-reviewedLead author
Arabidopsis AtIscA-I is affected by deficiency of Fe-S cluster biosynthetic scaffold AtCnfU-V.

Toshiki Yabe, Masato Nakai

Biochemical and Biophysical Research Communications, 340(4) 1047-1052, Feb, 2006 Peer-reviewedLead author
The Arabidopsis chloroplastic NifU-Like protein CnfU can act as an iron-sulfur cluster scaffold protein and is required for biogenesis of ferredoxin and photosystem I

Toshiki Yabe, Kozo Morimoto, Shingo Kikuchi, Kazuaki Nishio, Ichiro Terashima, Masato Nakai

Photosynthesis: Fundamental Aspects to Global Perspectives (A. van der Est, and D. Bruce. eds.), Kluwer Academic Publishers, Dordrecht, pp.793-795, 2005
The Arabidopsis chloroplastic NifU-like protein CnfU, which can act as an iron-sulfur cluster scaffold protein, is required for biogenesis of ferredoxin and photosystem I.

Toshiki Yabe, Kozo Morimoto, Shingo Kikuchi, Kazuaki Nishio, Ichiro Terashima, Masato Nakai

The Plant Cell, 16(4) 993-1007, Apr, 2004 Peer-reviewedLead author
鉄硫黄クラスターの生合成はどこまでわかったか？（総説）

矢部俊樹, 森本耕造, 中井正人

化学と生物, 41(10) 680-686, 2003 InvitedLead author

Research Projects

Sortilinの新規リガンド分泌機構の分子基盤とその好酸球における役割

科学研究費補助金(基盤研究(C)), 文部科学省, Apr, 2019 - Mar, 2023

和田俊樹
生体金属イオンシグナルによる新規サイトカイン産生制御機構の解明

科学研究費補助金(若手研究(B)), 文部科学省, Apr, 2016 - Mar, 2019

和田(矢部) 俊樹
TLR9シグナルの新規制御分子Sortilinの機能解析

科学研究費補助金(若手研究(B)), 若手研究(B), 文部科学省, Apr, 2013 - Mar, 2015
TLR9シグナルの新規制御分子Sortilinの機能解析

学術振興資金（若手研究者奨励金）, 日本私立学校振興・共済事業団, Apr, 2013 - Mar, 2014

和田俊樹
The structural basis of the Fe-S cluster biosynthesis

Grants-in-Aid for Scientific Research(若手研究(スタートアップ)), 若手研究(スタートアップ), Ministry of Education, Culture, Sports, Science and Technology, 2008 - 2009

Toshiki YABE
iron homeostasis

Research History

Jan, 2023 - Present

民間企業
Jan, 2016 - Dec, 2022

Senior Assistant Professor, School of Medicine, Kanazawa Medical University
Dec, 2011 - Dec, 2015

Assistant Professor, School of Medicine, Kanazawa Medical University
Apr, 2010 - Nov, 2011

Visiting fellow, National Institutes of Health
Nov, 2007 - Mar, 2010

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
Apr, 2007 - Oct, 2007

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
Apr, 2006 - Mar, 2007

Institute for Protein Research, Osaka University

Research Interests

Research Areas

Education

Apr, 2001 - Mar, 2006

Osaka University
Apr, 1997 - Mar, 2001

Kyoto Institute of Technology

Teaching Experience

免疫学 (金沢医科大学)

Professional Memberships

Misc.

Involvement of poly-rC binding proteins in posttranscriptional regulation of Sortilin, the cytokine trafficking mediator

Toshiki Yabe-Wada, Shintaro Matsuba, Kazuya Takeda, Akira Nakamura, Caroline C. Philpott, Nobuyuki Onai

CYTOKINE, 100 145-146, Dec, 2017
EACH MEMBER OF THE PCBP FILY EXHIBITS IRON CHAPERONE ACTIVITY TOWARD FERRITIN

Sebastien Leidgens, Kimberley Bullough, Haifeng Shi, Toshiki Yabe, Minoo Shakoury-Elizeh, Poorna Subramanian, Emory Hsu, Navin Natarayan, Anjali Nandal, Timothy Stemmler …

AMERICAN JOURNAL OF HEMATOLOGY, 88(5) E20-E20, May, 2013
ACTIVATION OF THE ESSENTIAL DIIRON ENZYME DEOXYHYPUSINE HYDROXYLASE BY THE IRON CHAPERONES PCBP1 AND PCBP2

Anjali Nandal, Avery Frey, Jong-Hwan Park, Toshiki Yabe, Myung-Hee Park, Caroline Philpott

AMERICAN JOURNAL OF HEMATOLOGY, 88(5) E197-E197, May, 2013
Biochemical properties of HCF101 involved in iron-sulfur cluster biosynthesis in plant chloroplasts

Toshiki Yabe, Hiroshi Hori, Masato Nakai

PLANT AND CELL PHYSIOLOGY, 48 S127-S127, 2007

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Research History

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Education

Teaching Experience

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